Cargando…

Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo

BACKGROUND: Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system (CNS). It is widely accepted that inflammatory cells play major roles in the pathogenesis of MS, possibly through the use of serine protease granzyme B (GrB) secreted from th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haile, Yohannes, Carmine-Simmen, Katia, Olechowski, Camille, Kerr, Bradley, Bleackley, R. Chris, Giuliani, Fabrizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558826/ https://www.ncbi.nlm.nih.gov/pubmed/26337722 http://dx.doi.org/10.1186/s12974-015-0376-7

Ejemplares similares

Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm
por: Ang, L S, et al.
Publicado: (2011)

Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm
por: Ang, L S, et al.
Publicado: (2011)

Therapeutical Significance of Serpina3n Subsequent Cerebral Ischemia via Cytotoxic Granzyme B Inactivation
por: Aslam, Mehwish Saba, et al.
Publicado: (2022)

Neuroprotective Effects of Serpina3k in Traumatic Brain Injury
por: Jing, Yao, et al.
Publicado: (2019)

In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis
por: Bezerra, Filipa, et al.
Publicado: (2021)

SERPINA3: Stimulator or Inhibitor of Pathological Changes
por: de Mezer, Mateusz, et al.
Publicado: (2023)

Serpina3n accelerates tissue repair in a diabetic mouse model of delayed wound healing
por: Hsu, I, et al.
Publicado: (2014)

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
por: Winkler, Ingrid G., et al.
Publicado: (2005)

Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells
por: Thiery, Jerome, et al.
Publicado: (2011)

Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax
por: Heibein, Jeffrey A., et al.
Publicado: (2000)

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis
por: Haile, Yohannes, et al.
Publicado: (2017)

SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1
por: Marques, Patrícia Isabel, et al.
Publicado: (2013)

Granzyme B Inhibits Vaccinia Virus Production through Proteolytic Cleavage of Eukaryotic Initiation Factor 4 Gamma 3
por: Marcet-Palacios, Marcelo, et al.
Publicado: (2011)

SERPINA3 in glioblastoma and Alzheimer’s disease
por: Norton, Emily S., et al.
Publicado: (2021)

Expression of SERPINA3s in cattle: focus on bovSERPINA3-7 reveals specific involvement in skeletal muscle
por: Péré-Brissaud, Antoine, et al.
Publicado: (2015)

Serpina3n/serpina3 alleviates cyclophosphamide-induced interstitial cystitis by activating the Wnt/β-catenin signal
por: Fang, Weilin, et al.
Publicado: (2023)

Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors
por: van Kempen, Pauline M. W., et al.
Publicado: (2016)

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET
por: Zhao, Ning, et al.
Publicado: (2021)

In Vitro and In Vivo Neuroprotective Effects of Sarcosine
por: Tanas, Arzugül, et al.
Publicado: (2022)

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin
por: Bolton, Jennifer L., et al.
Publicado: (2014)

Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation
por: Wang, Huiru, et al.
Publicado: (2015)

A combined in silico and in vitro study on mouse Serpina1a antitrypsin-deficiency mutants
por: Eggenschwiler, Reto, et al.
Publicado: (2019)

Granzymes—Their Role in Colorectal Cancer
por: Pączek, Sara, et al.
Publicado: (2022)

Neuroprotective Effects of the DPP4 Inhibitor Vildagliptin in In Vivo and In Vitro Models of Parkinson’s Disease
por: Pariyar, Ramesh, et al.
Publicado: (2022)

Granzyme B; the chalk-mark of a cytotoxic lymphocyte
por: Waterhouse, Nigel J, et al.
Publicado: (2004)

Differential overexpression of SERPINA3 in human prion diseases
por: Vanni, S., et al.
Publicado: (2017)

The Association and Pathogenesis of SERPINA3 in Coronary Artery Disease
por: Li, Bo, et al.
Publicado: (2021)

Increased SERPINA3 Level Is Associated with Ulcerative Colitis
por: Zhang, Jingwei, et al.
Publicado: (2021)

Potential impact of serpin peptidase inhibitor clade (A) member 4 SERPINA4 (rs2093266) and SERPINA5 (rs1955656) genetic variants on COVID-19 induced acute kidney injury
por: El-Hefnawy, Sally M., et al.
Publicado: (2022)

Neuroprotective Effects of Isoquercetin: An In Vitro and In Vivo Study
por: Yang, Qingxiao, et al.
Publicado: (2021)

Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo
por: Chen, Juan, et al.
Publicado: (2021)

Presence of Protease Inhibitor 9 and Granzyme B in Healthy and Pathological Human Corneas
por: Reinstein Merjava, Stanislava, et al.
Publicado: (2022)

Effective natural inhibitors targeting granzyme B in rheumatoid arthritis by computational study
por: Wang, Xinyu, et al.
Publicado: (2022)

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
por: Pardo, Julián, et al.
Publicado: (2004)

Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock
por: Vilander, Laura M., et al.
Publicado: (2017)

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo
por: Keuters, Meike Hedwig, et al.
Publicado: (2021)

Identification and characterisation of eight novel SERPINA1 Null mutations
por: Ferrarotti, Ilaria, et al.
Publicado: (2014)

Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta
por: Akbor, Maruf Mohammad, et al.
Publicado: (2021)

Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells
por: Kurowska, Patrycja, et al.
Publicado: (2021)

CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
por: Fissolo, Nicolás, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1tbm7iuk2fu97uj4o8o71chuoa