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Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer

We developed and validated an online questionnaire to document familial cancer history, in order to facilitate the detection of persons with a familial or hereditary colorectal cancer (CRC) risk. The development of the self-administered online questionnaire for the assessment of familial and heredit...

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Autores principales: Kallenberg, F. G. J., IJspeert, J. E. G., Bossuyt, P. M. M., Aalfs, C. M., Dekker, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559103/
https://www.ncbi.nlm.nih.gov/pubmed/25800523
http://dx.doi.org/10.1007/s10689-015-9792-1
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author Kallenberg, F. G. J.
IJspeert, J. E. G.
Bossuyt, P. M. M.
Aalfs, C. M.
Dekker, E.
author_facet Kallenberg, F. G. J.
IJspeert, J. E. G.
Bossuyt, P. M. M.
Aalfs, C. M.
Dekker, E.
author_sort Kallenberg, F. G. J.
collection PubMed
description We developed and validated an online questionnaire to document familial cancer history, in order to facilitate the detection of persons with a familial or hereditary colorectal cancer (CRC) risk. The development of the self-administered online questionnaire for the assessment of familial and hereditary CRC risk was based on nationwide criteria for referral to genetic specialists due to a Lynch syndrome suspicion, as well as existing criteria for surveillance colonoscopies because of an increased risk of familial CRC. The questionnaire was validated at a private colonoscopy center. Patients scheduled for colonoscopy were enrolled (n = 150). Performance of the questionnaire was assessed by comparing referrals based on questionnaire data against referral decisions based on full pedigree data. In a second validation phase, referrals based on questionnaire data were compared with referrals based on data collected in a telephone interview. We also calculated inter-observer agreement in referral decisions. In the first validation phase, the questionnaire had a sensitivity of 90 % (95 % CI 55–98 %) at a specificity of 98 % (95 % CI 87–100 %) in identifying persons qualifying for referral. In the second validation phase, sensitivity was 100 % (95 % CI 63–100) at a specificity of 97 % (95 % CI 91–99 %). In both validation phases an inter-observer agreement of 100 % in referral decisions was achieved. The online questionnaire has a high sensitivity and specificity in identifying persons qualifying for referral because of suspected Lynch syndrome or familial CRC. Implementation of this tool in colonoscopy clinics can facilitate the detection of patients with hereditary or familial CRC.
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spelling pubmed-45591032015-09-09 Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer Kallenberg, F. G. J. IJspeert, J. E. G. Bossuyt, P. M. M. Aalfs, C. M. Dekker, E. Fam Cancer Original Article We developed and validated an online questionnaire to document familial cancer history, in order to facilitate the detection of persons with a familial or hereditary colorectal cancer (CRC) risk. The development of the self-administered online questionnaire for the assessment of familial and hereditary CRC risk was based on nationwide criteria for referral to genetic specialists due to a Lynch syndrome suspicion, as well as existing criteria for surveillance colonoscopies because of an increased risk of familial CRC. The questionnaire was validated at a private colonoscopy center. Patients scheduled for colonoscopy were enrolled (n = 150). Performance of the questionnaire was assessed by comparing referrals based on questionnaire data against referral decisions based on full pedigree data. In a second validation phase, referrals based on questionnaire data were compared with referrals based on data collected in a telephone interview. We also calculated inter-observer agreement in referral decisions. In the first validation phase, the questionnaire had a sensitivity of 90 % (95 % CI 55–98 %) at a specificity of 98 % (95 % CI 87–100 %) in identifying persons qualifying for referral. In the second validation phase, sensitivity was 100 % (95 % CI 63–100) at a specificity of 97 % (95 % CI 91–99 %). In both validation phases an inter-observer agreement of 100 % in referral decisions was achieved. The online questionnaire has a high sensitivity and specificity in identifying persons qualifying for referral because of suspected Lynch syndrome or familial CRC. Implementation of this tool in colonoscopy clinics can facilitate the detection of patients with hereditary or familial CRC. Springer Netherlands 2015-03-24 2015 /pmc/articles/PMC4559103/ /pubmed/25800523 http://dx.doi.org/10.1007/s10689-015-9792-1 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Kallenberg, F. G. J.
IJspeert, J. E. G.
Bossuyt, P. M. M.
Aalfs, C. M.
Dekker, E.
Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer
title Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer
title_full Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer
title_fullStr Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer
title_full_unstemmed Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer
title_short Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer
title_sort validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559103/
https://www.ncbi.nlm.nih.gov/pubmed/25800523
http://dx.doi.org/10.1007/s10689-015-9792-1
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