Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

Systemic lupus erythematosus (SLE) patients exhibit depletion of the intracellular antioxidant glutathione and downstream activation of the metabolic sensor, mechanistic target of rapamycin (mTOR). Since reversal of glutathione depletion by the amino acid precursor, N-acetylcysteine (NAC), is therap...

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Detalles Bibliográficos
Autores principales: Perl, Andras, Hanczko, Robert, Lai, Zhi-Wei, Oaks, Zachary, Kelly, Ryan, Borsuk, Rebecca, Asara, John M., Phillips, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559110/
https://www.ncbi.nlm.nih.gov/pubmed/26366134
http://dx.doi.org/10.1007/s11306-015-0772-0

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