Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery

BACKGROUND: Since cancer cells are normally over-expressed cathepsin B, we synthesized dendrimer-methoxy poly(ethylene glycol) (MPEG)-doxorubicin (DOX) conjugates using a cathepsin B-cleavable peptide for anticancer drug targeting. METHODS: Gly-Phe-Leu-Gly peptide was conjugated with the carboxylic...

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Detalles Bibliográficos
Autores principales: Lee, Sang Joon, Jeong, Young-Il, Park, Hyung-Kyu, Kang, Dae Hwan, Oh, Jong-Suk, Lee, Sam-Gyu, Lee, Hyun Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559238/
https://www.ncbi.nlm.nih.gov/pubmed/26357473
http://dx.doi.org/10.2147/IJN.S87145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559238/
https://www.ncbi.nlm.nih.gov/pubmed/26357473
http://dx.doi.org/10.2147/IJN.S87145

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