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Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery

BACKGROUND: Since cancer cells are normally over-expressed cathepsin B, we synthesized dendrimer-methoxy poly(ethylene glycol) (MPEG)-doxorubicin (DOX) conjugates using a cathepsin B-cleavable peptide for anticancer drug targeting. METHODS: Gly-Phe-Leu-Gly peptide was conjugated with the carboxylic...

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Detalles Bibliográficos
Autores principales:	Lee, Sang Joon, Jeong, Young-Il, Park, Hyung-Kyu, Kang, Dae Hwan, Oh, Jong-Suk, Lee, Sam-Gyu, Lee, Hyun Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559238/ https://www.ncbi.nlm.nih.gov/pubmed/26357473 http://dx.doi.org/10.2147/IJN.S87145

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