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Sulindac, 3,3’-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis

BACKGROUND: Recently, we showed that Sulindac (SU; 320 ppm) reduces precancerous lesions in the colon of Pirc rats, mutated in the Apc gene. Surprisingly, previous data in Apc-mutated mice showed that SU, with reported efficacy in Familial Adenomatous Polyposis (FAP), increases colon carcinogenesis....

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Detalles Bibliográficos
Autores principales:	Femia, Angelo Pietro, Soares, Paulo Victoria, Luceri, Cristina, Lodovici, Maura, Giannini, Augusto, Caderni, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559292/ https://www.ncbi.nlm.nih.gov/pubmed/26335331 http://dx.doi.org/10.1186/s12885-015-1627-9

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