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Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease
OBJECTIVE: Little is known about the relationship between body composition indicators, including body mass index (BMI), fat mass index (FMI) and lean BMI (LBMI), and adverse outcomes after percutaneous coronary intervention (PCI) in Asian populations. The aim of this study was to clarify this relati...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559317/ https://www.ncbi.nlm.nih.gov/pubmed/26345318 http://dx.doi.org/10.1136/heartasia-2015-010644 |
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author | Hioki, Hirofumi Miura, Takashi Motoki, Hirohiko Kobayashi, Hideki Kobayashi, Masanori Nakajima, Hiroyuki Kimura, Hikaru Mawatari, Eiichiro Akanuma, Hiroshi Sato, Toshio Ebisawa, Souichirou Miyashita, Yusuke Ikeda, Uichi |
author_facet | Hioki, Hirofumi Miura, Takashi Motoki, Hirohiko Kobayashi, Hideki Kobayashi, Masanori Nakajima, Hiroyuki Kimura, Hikaru Mawatari, Eiichiro Akanuma, Hiroshi Sato, Toshio Ebisawa, Souichirou Miyashita, Yusuke Ikeda, Uichi |
author_sort | Hioki, Hirofumi |
collection | PubMed |
description | OBJECTIVE: Little is known about the relationship between body composition indicators, including body mass index (BMI), fat mass index (FMI) and lean BMI (LBMI), and adverse outcomes after percutaneous coronary intervention (PCI) in Asian populations. The aim of this study was to clarify this relationship. METHODS: The SHINANO registry is a prospective, observational, multicenter cohort registry that enrolled 1923 consecutive patients with coronary heart disease (CHD) from August 2012 to July 2013; 66 patients were excluded because of missing data. We evaluated 1857 patients with CHD who underwent PCI (aged 70±11 years; 23% women; BMI 23.8±3.5 kg/m(2); LBMI 18.3±1.8 kg/m(2); FMI 5.4±2.2 kg/m(2)). Patients were divided into three groups, based on BMI, LBMI and FMI tertiles, to assess the prognostic value of the three indicators. The primary endpoint was major adverse cardiac events (MACE), including all cause death, non-fatal myocardial infarction and ischaemic stroke at 1 year. RESULTS: Over a 1 year follow-up period (1776 patients, 95.6%), the cumulative MACE incidence was 8.7% (161 cases). Using Kaplan–Meier analysis, the MACE incidence was significantly higher in patients with lower BMI values (13.4–22.2 kg/m(2)) (p=0.002) and lower LBMI values (11.6–17.6 kg/m(2)) (p<0.001); this trend was not observed for FMI. Multivariate Cox regression analysis showed that lower LBMI but not lower BMI values were predictive of a higher MACE incidence (HR 1.55; 95% CI 1.05 to 2.30). CONCLUSIONS: Lower LBMI values are associated with adverse outcomes in an Asian population with CHD undergoing PCI. LBMI is a better predictor of MACE than BMI or FMI. CLINICAL TRIAL REGISTRATION: UMIN-ID; 000010070. |
format | Online Article Text |
id | pubmed-4559317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45593172015-09-04 Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease Hioki, Hirofumi Miura, Takashi Motoki, Hirohiko Kobayashi, Hideki Kobayashi, Masanori Nakajima, Hiroyuki Kimura, Hikaru Mawatari, Eiichiro Akanuma, Hiroshi Sato, Toshio Ebisawa, Souichirou Miyashita, Yusuke Ikeda, Uichi Heart Asia Cardiac Risk Factors and Prevention OBJECTIVE: Little is known about the relationship between body composition indicators, including body mass index (BMI), fat mass index (FMI) and lean BMI (LBMI), and adverse outcomes after percutaneous coronary intervention (PCI) in Asian populations. The aim of this study was to clarify this relationship. METHODS: The SHINANO registry is a prospective, observational, multicenter cohort registry that enrolled 1923 consecutive patients with coronary heart disease (CHD) from August 2012 to July 2013; 66 patients were excluded because of missing data. We evaluated 1857 patients with CHD who underwent PCI (aged 70±11 years; 23% women; BMI 23.8±3.5 kg/m(2); LBMI 18.3±1.8 kg/m(2); FMI 5.4±2.2 kg/m(2)). Patients were divided into three groups, based on BMI, LBMI and FMI tertiles, to assess the prognostic value of the three indicators. The primary endpoint was major adverse cardiac events (MACE), including all cause death, non-fatal myocardial infarction and ischaemic stroke at 1 year. RESULTS: Over a 1 year follow-up period (1776 patients, 95.6%), the cumulative MACE incidence was 8.7% (161 cases). Using Kaplan–Meier analysis, the MACE incidence was significantly higher in patients with lower BMI values (13.4–22.2 kg/m(2)) (p=0.002) and lower LBMI values (11.6–17.6 kg/m(2)) (p<0.001); this trend was not observed for FMI. Multivariate Cox regression analysis showed that lower LBMI but not lower BMI values were predictive of a higher MACE incidence (HR 1.55; 95% CI 1.05 to 2.30). CONCLUSIONS: Lower LBMI values are associated with adverse outcomes in an Asian population with CHD undergoing PCI. LBMI is a better predictor of MACE than BMI or FMI. CLINICAL TRIAL REGISTRATION: UMIN-ID; 000010070. BMJ Publishing Group 2015-08-26 /pmc/articles/PMC4559317/ /pubmed/26345318 http://dx.doi.org/10.1136/heartasia-2015-010644 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Cardiac Risk Factors and Prevention Hioki, Hirofumi Miura, Takashi Motoki, Hirohiko Kobayashi, Hideki Kobayashi, Masanori Nakajima, Hiroyuki Kimura, Hikaru Mawatari, Eiichiro Akanuma, Hiroshi Sato, Toshio Ebisawa, Souichirou Miyashita, Yusuke Ikeda, Uichi Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease |
title | Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease |
title_full | Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease |
title_fullStr | Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease |
title_full_unstemmed | Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease |
title_short | Lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease |
title_sort | lean body mass index prognostic value for cardiovascular events in patients with coronary artery disease |
topic | Cardiac Risk Factors and Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559317/ https://www.ncbi.nlm.nih.gov/pubmed/26345318 http://dx.doi.org/10.1136/heartasia-2015-010644 |
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