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Silver nanoparticle protein corona and toxicity: a mini-review
Silver nanoparticles are one of the most important materials in the nanotechnology industry. Additionally, the protein corona is emerging as a key entity at the nanobiointerface; thus, a comprehensive understanding of the interactions between proteins and silver nanoparticles is imperative. Therefor...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559354/ https://www.ncbi.nlm.nih.gov/pubmed/26337542 http://dx.doi.org/10.1186/s12951-015-0114-4 |
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author | Durán, Nelson Silveira, Camila P. Durán, Marcela Martinez, Diego Stéfani T. |
author_facet | Durán, Nelson Silveira, Camila P. Durán, Marcela Martinez, Diego Stéfani T. |
author_sort | Durán, Nelson |
collection | PubMed |
description | Silver nanoparticles are one of the most important materials in the nanotechnology industry. Additionally, the protein corona is emerging as a key entity at the nanobiointerface; thus, a comprehensive understanding of the interactions between proteins and silver nanoparticles is imperative. Therefore, literature reporting studies involving both single molecule protein coronas (i.e., bovine and human serum albumin, tubulin, ubiquitin and hyaluronic-binding protein) and complex protein coronas (i.e., fetal bovine serum and yeast extract proteins) were selected to demonstrate the effects of protein coronas on silver nanoparticle cytotoxicity and antimicrobial activity. There is evidence that distinct and differential protein components may yield a “protein corona signature” that is related to the size and/or surface curvature of the silver nanoparticles. Therefore, the formation of silver nanoparticle protein coronas together with the biological response to these coronas (i.e., oxidative stress, inflammation and cytotoxicity) as well as other cellular biophysicochemical mechanisms (i.e., endocytosis, biotransformation and biodistribution) will be important for nanomedicine and nanotoxicology. Researchers may benefit from the information contained herein to improve biotechnological applications of silver nanoparticles and to address related safety concerns. In summary, the main aim of this mini-review is to highlight the relationship between the formation of silver nanoparticle protein coronas and toxicity. |
format | Online Article Text |
id | pubmed-4559354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45593542015-09-04 Silver nanoparticle protein corona and toxicity: a mini-review Durán, Nelson Silveira, Camila P. Durán, Marcela Martinez, Diego Stéfani T. J Nanobiotechnology Review Silver nanoparticles are one of the most important materials in the nanotechnology industry. Additionally, the protein corona is emerging as a key entity at the nanobiointerface; thus, a comprehensive understanding of the interactions between proteins and silver nanoparticles is imperative. Therefore, literature reporting studies involving both single molecule protein coronas (i.e., bovine and human serum albumin, tubulin, ubiquitin and hyaluronic-binding protein) and complex protein coronas (i.e., fetal bovine serum and yeast extract proteins) were selected to demonstrate the effects of protein coronas on silver nanoparticle cytotoxicity and antimicrobial activity. There is evidence that distinct and differential protein components may yield a “protein corona signature” that is related to the size and/or surface curvature of the silver nanoparticles. Therefore, the formation of silver nanoparticle protein coronas together with the biological response to these coronas (i.e., oxidative stress, inflammation and cytotoxicity) as well as other cellular biophysicochemical mechanisms (i.e., endocytosis, biotransformation and biodistribution) will be important for nanomedicine and nanotoxicology. Researchers may benefit from the information contained herein to improve biotechnological applications of silver nanoparticles and to address related safety concerns. In summary, the main aim of this mini-review is to highlight the relationship between the formation of silver nanoparticle protein coronas and toxicity. BioMed Central 2015-09-04 /pmc/articles/PMC4559354/ /pubmed/26337542 http://dx.doi.org/10.1186/s12951-015-0114-4 Text en © Durán et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Durán, Nelson Silveira, Camila P. Durán, Marcela Martinez, Diego Stéfani T. Silver nanoparticle protein corona and toxicity: a mini-review |
title | Silver nanoparticle protein corona and toxicity: a mini-review |
title_full | Silver nanoparticle protein corona and toxicity: a mini-review |
title_fullStr | Silver nanoparticle protein corona and toxicity: a mini-review |
title_full_unstemmed | Silver nanoparticle protein corona and toxicity: a mini-review |
title_short | Silver nanoparticle protein corona and toxicity: a mini-review |
title_sort | silver nanoparticle protein corona and toxicity: a mini-review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559354/ https://www.ncbi.nlm.nih.gov/pubmed/26337542 http://dx.doi.org/10.1186/s12951-015-0114-4 |
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