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ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1

BACKGROUND: The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due to the embryonic lethality of ERK2 k...

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Detalles Bibliográficos
Autores principales:	Buscà, Roser, Christen, Richard, Lovern, Matthew, Clifford, Alexander M., Yue, Jia-Xing, Goss, Greg G., Pouysségur, Jacques, Lenormand, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559367/ https://www.ncbi.nlm.nih.gov/pubmed/26336084 http://dx.doi.org/10.1186/s12862-015-0450-x

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