New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients

Leprosy control is achieved through a fine-tuning of T(H)1 and T(H)2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time...

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Autores principales: Papotto, Pedro Henrique, Maeda, Solange, Tomimori, Jane, Xavier, Marília Brasil, Rizzo, Luiz Vicente, Kallas, Esper Georges, Carvalho, Karina Inácio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559394/
https://www.ncbi.nlm.nih.gov/pubmed/26335023
http://dx.doi.org/10.1371/journal.pntd.0004030
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author Papotto, Pedro Henrique
Maeda, Solange
Tomimori, Jane
Xavier, Marília Brasil
Rizzo, Luiz Vicente
Kallas, Esper Georges
Carvalho, Karina Inácio
author_facet Papotto, Pedro Henrique
Maeda, Solange
Tomimori, Jane
Xavier, Marília Brasil
Rizzo, Luiz Vicente
Kallas, Esper Georges
Carvalho, Karina Inácio
author_sort Papotto, Pedro Henrique
collection PubMed
description Leprosy control is achieved through a fine-tuning of T(H)1 and T(H)2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.
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spelling pubmed-45593942015-09-10 New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients Papotto, Pedro Henrique Maeda, Solange Tomimori, Jane Xavier, Marília Brasil Rizzo, Luiz Vicente Kallas, Esper Georges Carvalho, Karina Inácio PLoS Negl Trop Dis Research Article Leprosy control is achieved through a fine-tuning of T(H)1 and T(H)2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function. Public Library of Science 2015-09-03 /pmc/articles/PMC4559394/ /pubmed/26335023 http://dx.doi.org/10.1371/journal.pntd.0004030 Text en © 2015 Papotto et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Papotto, Pedro Henrique
Maeda, Solange
Tomimori, Jane
Xavier, Marília Brasil
Rizzo, Luiz Vicente
Kallas, Esper Georges
Carvalho, Karina Inácio
New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients
title New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients
title_full New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients
title_fullStr New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients
title_full_unstemmed New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients
title_short New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients
title_sort new players in the same old game: disturbance of group 2 innate lymphoid cells in hiv-1 and mycobacterium leprae co-infected patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559394/
https://www.ncbi.nlm.nih.gov/pubmed/26335023
http://dx.doi.org/10.1371/journal.pntd.0004030
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