HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE(-/-) Mice: Evidence of ABCA1 Down-Regulation

OBJECTIVE: CER-001 is a novel engineered HDL-mimetic comprised of recombinant human apoA-I and charged phospholipids that was designed to mimic the beneficial properties of nascent pre-ß HDL. In this study, we have evaluated the dose-dependent regulation of ABCA1 expression in vitro and in vivo in t...

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Detalles Bibliográficos
Autores principales: Tardy, Claudine, Goffinet, Marine, Boubekeur, Nadia, Cholez, Guy, Ackermann, Rose, Sy, Gavin, Keyserling, Constance, Lalwani, Narendra, Paolini, John F., Dasseux, Jean-Louis, Barbaras, Ronald, Baron, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559410/
https://www.ncbi.nlm.nih.gov/pubmed/26335690
http://dx.doi.org/10.1371/journal.pone.0137584

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