Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence

Vaccinia virus (VACV) is the prototypic orthopoxvirus and the vaccine used to eradicate smallpox. Here we show that VACV strain Western Reserve protein 169 is a cytoplasmic polypeptide expressed early during infection that is excluded from virus factories and inhibits the initiation of cap-dependent...

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Detalles Bibliográficos
Autores principales: Strnadova, Pavla, Ren, Hongwei, Valentine, Robert, Mazzon, Michela, Sweeney, Trevor R., Brierley, Ian, Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559412/
https://www.ncbi.nlm.nih.gov/pubmed/26334635
http://dx.doi.org/10.1371/journal.ppat.1005151

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