Cargando…
The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs
The intraerythrocytic malaria parasite, Plasmodium falciparum, maintains a low cytosolic Na(+) concentration and the plasma membrane P-type cation translocating ATPase ‘PfATP4’ has been implicated as playing a key role in this process. PfATP4 has been the subject of significant attention in recent y...
Autores principales: | Spillman, Natalie Jane, Kirk, Kiaran |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559606/ https://www.ncbi.nlm.nih.gov/pubmed/26401486 http://dx.doi.org/10.1016/j.ijpddr.2015.07.001 |
Ejemplares similares
-
Na(+) Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
por: Spillman, Natalie J., et al.
Publicado: (2013) -
Mutations in the P-Type Cation-Transporter
ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone
Antimalarials
por: Flannery, Erika L., et al.
Publicado: (2014) -
Optimization of
2,3-Dihydroquinazolinone-3-carboxamides
as Antimalarials Targeting PfATP4
por: Ashton, Trent D., et al.
Publicado: (2023) -
Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach
por: N., Nagasundaram, et al.
Publicado: (2016) -
Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors
por: Tewari, Shivendra G., et al.
Publicado: (2023)