EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway

Malignant pleural effusion (MPE) is a common clinical problem in non-small cell lung carcinoma (NSCLC) patients; however, the underlying mechanisms are still largely unknown. Recent studies indicate that the frequency of the L858R mutant form of the epidermal growth factor receptor (EGFR-L858R) is h...

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Detalles Bibliográficos
Autores principales: Tsai, Meng-Feng, Chang, Tzu-Hua, Wu, Shang-Gin, Yang, Hsiao-Yin, Hsu, Yi-Chiung, Yang, Pan-Chyr, Shih, Jin-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559673/
https://www.ncbi.nlm.nih.gov/pubmed/26338423
http://dx.doi.org/10.1038/srep13574

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