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Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques

Atherosclerosis is an inflammatory disease as well as a lipid disorder. Atherosclerotic plaque formed in vessel walls may cause ischemia, and the rupture of vulnerable plaque may result in fatal events, like myocardial infarction or stroke. Because morphological imaging has limitations in diagnosing...

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Detalles Bibliográficos
Autores principales: Lee, Soo Jin, Paeng, Jin Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559792/
https://www.ncbi.nlm.nih.gov/pubmed/26357491
http://dx.doi.org/10.3348/kjr.2015.16.5.955
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author Lee, Soo Jin
Paeng, Jin Chul
author_facet Lee, Soo Jin
Paeng, Jin Chul
author_sort Lee, Soo Jin
collection PubMed
description Atherosclerosis is an inflammatory disease as well as a lipid disorder. Atherosclerotic plaque formed in vessel walls may cause ischemia, and the rupture of vulnerable plaque may result in fatal events, like myocardial infarction or stroke. Because morphological imaging has limitations in diagnosing vulnerable plaque, molecular imaging has been developed, in particular, the use of nuclear imaging probes. Molecular imaging targets various aspects of vulnerable plaque, such as inflammatory cell accumulation, endothelial activation, proteolysis, neoangiogenesis, hypoxia, apoptosis, and calcification. Many preclinical and clinical studies have been conducted with various imaging probes and some of them have exhibited promising results. Despite some limitations in imaging technology, molecular imaging is expected to be used both in the research and clinical fields as imaging instruments become more advanced.
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spelling pubmed-45597922015-09-09 Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques Lee, Soo Jin Paeng, Jin Chul Korean J Radiol Nuclear Medicine Atherosclerosis is an inflammatory disease as well as a lipid disorder. Atherosclerotic plaque formed in vessel walls may cause ischemia, and the rupture of vulnerable plaque may result in fatal events, like myocardial infarction or stroke. Because morphological imaging has limitations in diagnosing vulnerable plaque, molecular imaging has been developed, in particular, the use of nuclear imaging probes. Molecular imaging targets various aspects of vulnerable plaque, such as inflammatory cell accumulation, endothelial activation, proteolysis, neoangiogenesis, hypoxia, apoptosis, and calcification. Many preclinical and clinical studies have been conducted with various imaging probes and some of them have exhibited promising results. Despite some limitations in imaging technology, molecular imaging is expected to be used both in the research and clinical fields as imaging instruments become more advanced. The Korean Society of Radiology 2015 2015-08-21 /pmc/articles/PMC4559792/ /pubmed/26357491 http://dx.doi.org/10.3348/kjr.2015.16.5.955 Text en Copyright © 2015 The Korean Society of Radiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nuclear Medicine
Lee, Soo Jin
Paeng, Jin Chul
Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques
title Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques
title_full Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques
title_fullStr Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques
title_full_unstemmed Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques
title_short Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques
title_sort nuclear molecular imaging for vulnerable atherosclerotic plaques
topic Nuclear Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559792/
https://www.ncbi.nlm.nih.gov/pubmed/26357491
http://dx.doi.org/10.3348/kjr.2015.16.5.955
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