RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect

Hypoxia-inducible factors (HIFs) are master regulators of adaptive responses to low oxygen, and their α-subunits are rapidly degraded through the ubiquitination-dependent proteasomal pathway after hydroxylation. Aberrant accumulation or activation of HIFs is closely linked to many types of cancer. H...

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Detalles Bibliográficos
Autores principales: Zhang, Chen-Song, Liu, Qi, Li, Mengqi, Lin, Shu-Yong, Peng, Yongying, Wu, Di, Li, Terytty Yang, Fu, Qiang, Jia, Weiping, Wang, Xinjun, Ma, Teng, Zong, Yue, Cui, Jiwen, Pu, Chengfei, Lian, Guili, Guo, Huiling, Ye, Zhiyun, Lin, Sheng-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559813/
https://www.ncbi.nlm.nih.gov/pubmed/26215701
http://dx.doi.org/10.1038/cr.2015.90

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