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Clinical characteristics of protracted bacterial bronchitis in Chinese infants

Protracted bacterial bronchitis (PBB) is the common cause of chronic cough in children worldwide, but its etiology has not been fully recognized in China. We retrospectively investigated a total of 66 hospitalized infants under the age of three years with chronic wet cough enrolled in the Affiliated...

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Autores principales: Wang, Yuqing, Hao, Chuangli, Chi, FanFan, Yu, Xingmei, Sun, Huiquan, Huang, Li, Wang, Meijuan, Ji, Wei, Yan, Yongdong, Zhu, Hong, Shao, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559899/
https://www.ncbi.nlm.nih.gov/pubmed/26338462
http://dx.doi.org/10.1038/srep13731
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author Wang, Yuqing
Hao, Chuangli
Chi, FanFan
Yu, Xingmei
Sun, Huiquan
Huang, Li
Wang, Meijuan
Ji, Wei
Yan, Yongdong
Zhu, Hong
Shao, Xuejun
author_facet Wang, Yuqing
Hao, Chuangli
Chi, FanFan
Yu, Xingmei
Sun, Huiquan
Huang, Li
Wang, Meijuan
Ji, Wei
Yan, Yongdong
Zhu, Hong
Shao, Xuejun
author_sort Wang, Yuqing
collection PubMed
description Protracted bacterial bronchitis (PBB) is the common cause of chronic cough in children worldwide, but its etiology has not been fully recognized in China. We retrospectively investigated a total of 66 hospitalized infants under the age of three years with chronic wet cough enrolled in the Affiliated Children’s Hospital of Soochow University from October 2010 to March 2014. All patients underwent bronchoscopy and broncho-alveolar lavage (BAL) samples were processed for microbiological and cytological analysis. Of 66 patients with wet cough, 50 (75.8%) were diagnosed with PBB. In the PBB group, wet cough was accompanied by wheezing (90%). Airway malacia were identified in 22 cases (44%). The clinical manifestations of PBB with airway malacia did not differ from those without malacia. Haemophilus influenzae (47.4%) and Streptococcus pneumoniae (36.8%) were the most commonly identified pathogens. Furthermore, CD3(+) and CD3(+)CD4(+) cells were significantly lower in the PBB group (p < 0.01), while CD19(+), CD16(+)CD56(+) and CD23(+) cells were elevated (p < 0.01) in the PBB group. Our study revealed PBB is an important cause of chronic wet cough in Chinese infants, and that changes of lymphocyte subsets are observed in children with PBB. Airway malacia frequently co-existed with PBB, but did not exacerbate the disease.
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spelling pubmed-45598992015-09-11 Clinical characteristics of protracted bacterial bronchitis in Chinese infants Wang, Yuqing Hao, Chuangli Chi, FanFan Yu, Xingmei Sun, Huiquan Huang, Li Wang, Meijuan Ji, Wei Yan, Yongdong Zhu, Hong Shao, Xuejun Sci Rep Article Protracted bacterial bronchitis (PBB) is the common cause of chronic cough in children worldwide, but its etiology has not been fully recognized in China. We retrospectively investigated a total of 66 hospitalized infants under the age of three years with chronic wet cough enrolled in the Affiliated Children’s Hospital of Soochow University from October 2010 to March 2014. All patients underwent bronchoscopy and broncho-alveolar lavage (BAL) samples were processed for microbiological and cytological analysis. Of 66 patients with wet cough, 50 (75.8%) were diagnosed with PBB. In the PBB group, wet cough was accompanied by wheezing (90%). Airway malacia were identified in 22 cases (44%). The clinical manifestations of PBB with airway malacia did not differ from those without malacia. Haemophilus influenzae (47.4%) and Streptococcus pneumoniae (36.8%) were the most commonly identified pathogens. Furthermore, CD3(+) and CD3(+)CD4(+) cells were significantly lower in the PBB group (p < 0.01), while CD19(+), CD16(+)CD56(+) and CD23(+) cells were elevated (p < 0.01) in the PBB group. Our study revealed PBB is an important cause of chronic wet cough in Chinese infants, and that changes of lymphocyte subsets are observed in children with PBB. Airway malacia frequently co-existed with PBB, but did not exacerbate the disease. Nature Publishing Group 2015-09-04 /pmc/articles/PMC4559899/ /pubmed/26338462 http://dx.doi.org/10.1038/srep13731 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Yuqing
Hao, Chuangli
Chi, FanFan
Yu, Xingmei
Sun, Huiquan
Huang, Li
Wang, Meijuan
Ji, Wei
Yan, Yongdong
Zhu, Hong
Shao, Xuejun
Clinical characteristics of protracted bacterial bronchitis in Chinese infants
title Clinical characteristics of protracted bacterial bronchitis in Chinese infants
title_full Clinical characteristics of protracted bacterial bronchitis in Chinese infants
title_fullStr Clinical characteristics of protracted bacterial bronchitis in Chinese infants
title_full_unstemmed Clinical characteristics of protracted bacterial bronchitis in Chinese infants
title_short Clinical characteristics of protracted bacterial bronchitis in Chinese infants
title_sort clinical characteristics of protracted bacterial bronchitis in chinese infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559899/
https://www.ncbi.nlm.nih.gov/pubmed/26338462
http://dx.doi.org/10.1038/srep13731
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