Dimeric interactions and complex formation using direct coevolutionary couplings

We develop a procedure to characterize the association of protein structures into homodimers using coevolutionary couplings extracted from Direct Coupling Analysis (DCA) in combination with Structure Based Models (SBM). Identification of dimerization contacts using DCA is more challenging than intra...

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Detalles Bibliográficos
Autores principales: dos Santos, Ricardo N., Morcos, Faruck, Jana, Biman, Andricopulo, Adriano D., Onuchic, José N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559900/
https://www.ncbi.nlm.nih.gov/pubmed/26338201
http://dx.doi.org/10.1038/srep13652

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