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Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus

BACKGROUND: Ambient air pollution has been linked to the development of gestational diabetes mellitus (GDM). However, evidence of the association is very limited, and no study has estimated the effects of ozone. OBJECTIVE: Our aim was to determine the association of prenatal exposures to particulate...

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Autores principales: Hu, Hui, Ha, Sandie, Henderson, Barron H., Warner, Tamara D., Roth, Jeffrey, Kan, Haidong, Xu, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: NLM-Export 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559952/
https://www.ncbi.nlm.nih.gov/pubmed/25794412
http://dx.doi.org/10.1289/ehp.1408456
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author Hu, Hui
Ha, Sandie
Henderson, Barron H.
Warner, Tamara D.
Roth, Jeffrey
Kan, Haidong
Xu, Xiaohui
author_facet Hu, Hui
Ha, Sandie
Henderson, Barron H.
Warner, Tamara D.
Roth, Jeffrey
Kan, Haidong
Xu, Xiaohui
author_sort Hu, Hui
collection PubMed
description BACKGROUND: Ambient air pollution has been linked to the development of gestational diabetes mellitus (GDM). However, evidence of the association is very limited, and no study has estimated the effects of ozone. OBJECTIVE: Our aim was to determine the association of prenatal exposures to particulate matter ≤ 2.5 μm (PM(2.5)) and ozone (O(3)) with GDM. METHODS: We used Florida birth vital statistics records to investigate the association between the risk of GDM and two air pollutants (PM(2.5) and O(3)) among 410,267 women who gave birth in Florida between 2004 and 2005. Individual air pollution exposure was assessed at the woman’s home address at time of delivery using the hierarchical Bayesian space–time statistical model. We further estimated associations between air pollution exposures during different trimesters and GDM. RESULTS: After controlling for nine covariates, we observed increased odds of GDM with per 5-μg/m(3) increase in PM(2.5) (OR(Trimester1) = 1.16; 95% CI: 1.11, 1.21; OR(Trimester2) = 1.15; 95% CI: 1.10, 1.20; OR(Pregnancy) = 1.20; 95% CI: 1.13, 1.26) and per 5-ppb increase in O(3) (OR(Trimester1) = 1.09; 95% CI: 1.07, 1.11; OR(Trimester2) = 1.12; 95% CI: 1.10, 1.14; OR(Pregnancy) = 1.18; 95% CI: 1.15, 1.21) during both the first trimester and second trimester as well as the full pregnancy in single-pollutant models. Compared with the single-pollutant model, the ORs for O(3) were almost identical in the co-pollutant model. However, the ORs for PM(2.5) during the first trimester and the full pregnancy were attenuated, and no association was observed for PM(2.5) during the second trimester in the co-pollutant model (OR = 1.02; 95% CI: 0.98, 1.07). CONCLUSION: This population-based study suggests that exposure to air pollution during pregnancy is associated with increased risk of GDM in Florida, USA. CITATION: Hu H, Ha S, Henderson BH, Warner TD, Roth J, Kan H, Xu X. 2015. Association of atmospheric particulate matter and ozone with gestational diabetes mellitus. Environ Health Perspect 123:853–859; http://dx.doi.org/10.1289/ehp.1408456
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spelling pubmed-45599522015-09-10 Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus Hu, Hui Ha, Sandie Henderson, Barron H. Warner, Tamara D. Roth, Jeffrey Kan, Haidong Xu, Xiaohui Environ Health Perspect Research BACKGROUND: Ambient air pollution has been linked to the development of gestational diabetes mellitus (GDM). However, evidence of the association is very limited, and no study has estimated the effects of ozone. OBJECTIVE: Our aim was to determine the association of prenatal exposures to particulate matter ≤ 2.5 μm (PM(2.5)) and ozone (O(3)) with GDM. METHODS: We used Florida birth vital statistics records to investigate the association between the risk of GDM and two air pollutants (PM(2.5) and O(3)) among 410,267 women who gave birth in Florida between 2004 and 2005. Individual air pollution exposure was assessed at the woman’s home address at time of delivery using the hierarchical Bayesian space–time statistical model. We further estimated associations between air pollution exposures during different trimesters and GDM. RESULTS: After controlling for nine covariates, we observed increased odds of GDM with per 5-μg/m(3) increase in PM(2.5) (OR(Trimester1) = 1.16; 95% CI: 1.11, 1.21; OR(Trimester2) = 1.15; 95% CI: 1.10, 1.20; OR(Pregnancy) = 1.20; 95% CI: 1.13, 1.26) and per 5-ppb increase in O(3) (OR(Trimester1) = 1.09; 95% CI: 1.07, 1.11; OR(Trimester2) = 1.12; 95% CI: 1.10, 1.14; OR(Pregnancy) = 1.18; 95% CI: 1.15, 1.21) during both the first trimester and second trimester as well as the full pregnancy in single-pollutant models. Compared with the single-pollutant model, the ORs for O(3) were almost identical in the co-pollutant model. However, the ORs for PM(2.5) during the first trimester and the full pregnancy were attenuated, and no association was observed for PM(2.5) during the second trimester in the co-pollutant model (OR = 1.02; 95% CI: 0.98, 1.07). CONCLUSION: This population-based study suggests that exposure to air pollution during pregnancy is associated with increased risk of GDM in Florida, USA. CITATION: Hu H, Ha S, Henderson BH, Warner TD, Roth J, Kan H, Xu X. 2015. Association of atmospheric particulate matter and ozone with gestational diabetes mellitus. Environ Health Perspect 123:853–859; http://dx.doi.org/10.1289/ehp.1408456 NLM-Export 2015-03-20 2015-09 /pmc/articles/PMC4559952/ /pubmed/25794412 http://dx.doi.org/10.1289/ehp.1408456 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Hu, Hui
Ha, Sandie
Henderson, Barron H.
Warner, Tamara D.
Roth, Jeffrey
Kan, Haidong
Xu, Xiaohui
Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus
title Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus
title_full Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus
title_fullStr Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus
title_full_unstemmed Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus
title_short Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus
title_sort association of atmospheric particulate matter and ozone with gestational diabetes mellitus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559952/
https://www.ncbi.nlm.nih.gov/pubmed/25794412
http://dx.doi.org/10.1289/ehp.1408456
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