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Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates
Sumoylation during genotoxic stress regulates the composition of DNA repair complexes. The yeast metalloprotease Wss1 clears chromatin-bound sumoylated proteins. Wss1 and its mammalian analog, DVC1/Spartan, belong to minigluzincins family of proteases. Wss1 proteolytic activity is regulated by a cys...
Autores principales: | Balakirev, Maxim Y, Mullally, James E, Favier, Adrien, Assard, Nicole, Sulpice, Eric, Lindsey, David F, Rulina, Anastasia V, Gidrol, Xavier, Wilkinson, Keith D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559962/ https://www.ncbi.nlm.nih.gov/pubmed/26349035 http://dx.doi.org/10.7554/eLife.06763 |
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