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CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells

CCR5 is a chemokine receptor expressed on leukocytes and a coreceptor used by HIV-1 to enter CD4(+) T lymphocytes and macrophages. Stimulation of CCR5 by chemokines triggers internalization of chemokine-bound CCR5 molecules in a process called down-modulation, which contributes to the anti-HIV activ...

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Detalles Bibliográficos
Autores principales:	Fox, James M., Kasprowicz, Richard, Hartley, Oliver, Signoret, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Leukocyte Biology 2015
Materias:	Receptors, Signal Transduction, & Genes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560160/ https://www.ncbi.nlm.nih.gov/pubmed/25957306 http://dx.doi.org/10.1189/jlb.2A0414-193RR

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