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Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report
A 68-year-old man presented with gross hematuria. A papillary urethral tumor adjacent to the verumontanum was found by cystourethroscopy. Serum prostate-specific antigen (PSA) was 3.246 ng/ml. A transurethral biopsy specimen was most suggestive of a primary urothelial carcinoma of the prostate, for...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560301/ https://www.ncbi.nlm.nih.gov/pubmed/26351443 http://dx.doi.org/10.1159/000438785 |
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author | Fujiwara, Ryo Kageyama, Susumu Tomita, Keiji Hanada, Eiki Tsuru, Teruhiko Yoshida, Tetsuya Narita, Mitsuhiro Isono, Takahiro Kawauchi, Akihiro |
author_facet | Fujiwara, Ryo Kageyama, Susumu Tomita, Keiji Hanada, Eiki Tsuru, Teruhiko Yoshida, Tetsuya Narita, Mitsuhiro Isono, Takahiro Kawauchi, Akihiro |
author_sort | Fujiwara, Ryo |
collection | PubMed |
description | A 68-year-old man presented with gross hematuria. A papillary urethral tumor adjacent to the verumontanum was found by cystourethroscopy. Serum prostate-specific antigen (PSA) was 3.246 ng/ml. A transurethral biopsy specimen was most suggestive of a primary urothelial carcinoma of the prostate, for which a radical cystoprostatectomy was performed. The final pathology was prostatic ductal adenocarcinoma with very focal acinar features (Gleason score 5 %plus; 4 = 9, pT3bN0M0). Local recurrence and pelvic bone metastases developed 17 months later, and his PSA rose to 10.806 ng/ml. He was treated with combined androgen blockade and radiation. Two years later, the lesion showed progressive growth. Treatment followed with docetaxel (70 mg/m(2) every 3 weeks) and prednisolone 5 mg twice daily. After 10 cycles of chemotherapy, all lesions disappeared and PSA decreased to <0.005 ng/ml. Three years after chemotherapy, he maintains a complete response without any additional treatments. Docetaxel chemotherapy can be an effective treatment for patients with recurrent prostatic ductal adenocarcinoma. |
format | Online Article Text |
id | pubmed-4560301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-45603012015-09-08 Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report Fujiwara, Ryo Kageyama, Susumu Tomita, Keiji Hanada, Eiki Tsuru, Teruhiko Yoshida, Tetsuya Narita, Mitsuhiro Isono, Takahiro Kawauchi, Akihiro Case Rep Oncol Published online: August, 2015 A 68-year-old man presented with gross hematuria. A papillary urethral tumor adjacent to the verumontanum was found by cystourethroscopy. Serum prostate-specific antigen (PSA) was 3.246 ng/ml. A transurethral biopsy specimen was most suggestive of a primary urothelial carcinoma of the prostate, for which a radical cystoprostatectomy was performed. The final pathology was prostatic ductal adenocarcinoma with very focal acinar features (Gleason score 5 %plus; 4 = 9, pT3bN0M0). Local recurrence and pelvic bone metastases developed 17 months later, and his PSA rose to 10.806 ng/ml. He was treated with combined androgen blockade and radiation. Two years later, the lesion showed progressive growth. Treatment followed with docetaxel (70 mg/m(2) every 3 weeks) and prednisolone 5 mg twice daily. After 10 cycles of chemotherapy, all lesions disappeared and PSA decreased to <0.005 ng/ml. Three years after chemotherapy, he maintains a complete response without any additional treatments. Docetaxel chemotherapy can be an effective treatment for patients with recurrent prostatic ductal adenocarcinoma. S. Karger AG 2015-08-05 /pmc/articles/PMC4560301/ /pubmed/26351443 http://dx.doi.org/10.1159/000438785 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. |
spellingShingle | Published online: August, 2015 Fujiwara, Ryo Kageyama, Susumu Tomita, Keiji Hanada, Eiki Tsuru, Teruhiko Yoshida, Tetsuya Narita, Mitsuhiro Isono, Takahiro Kawauchi, Akihiro Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report |
title | Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report |
title_full | Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report |
title_fullStr | Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report |
title_full_unstemmed | Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report |
title_short | Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report |
title_sort | metastatic prostatic ductal adenocarcinoma successfully treated with docetaxel chemotherapy: a case report |
topic | Published online: August, 2015 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560301/ https://www.ncbi.nlm.nih.gov/pubmed/26351443 http://dx.doi.org/10.1159/000438785 |
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