Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis

Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the cour...

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Autores principales: Sato, Mika, Mizuno, Yuki, Matsuyama, Kanako, Shu, En, Kanoh, Hiroyuki, Suwa, Tetsuya, Seishima, Mariko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Published online: July, 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560312/
https://www.ncbi.nlm.nih.gov/pubmed/26351424
http://dx.doi.org/10.1159/000437251
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author Sato, Mika
Mizuno, Yuki
Matsuyama, Kanako
Shu, En
Kanoh, Hiroyuki
Suwa, Tetsuya
Seishima, Mariko
author_facet Sato, Mika
Mizuno, Yuki
Matsuyama, Kanako
Shu, En
Kanoh, Hiroyuki
Suwa, Tetsuya
Seishima, Mariko
author_sort Sato, Mika
collection PubMed
description Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the course of DIHS. We report a case of salazosulfapyridine-induced DIHS associated with HHV-6 reactivation. Two and a half months after the onset of DIHS, subacute thyroiditis occurred, possibly associated with CMV reactivation. Prednisolone (20 mg/day) was effective for subacute thyroiditis. Long-term follow-up is needed in patients with DIHS because of the possible onset of autoimmune diseases.
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spelling pubmed-45603122015-09-08 Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis Sato, Mika Mizuno, Yuki Matsuyama, Kanako Shu, En Kanoh, Hiroyuki Suwa, Tetsuya Seishima, Mariko Case Rep Dermatol Published online: July, 2015 Drug-induced hypersensitivity syndrome (DIHS) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (HHVs) such as HHV-6, HHV-7, cytomegalovirus (CMV) and Epstein-Barr virus. Various complications, including autoimmune diseases, sometimes appear during the course of DIHS. We report a case of salazosulfapyridine-induced DIHS associated with HHV-6 reactivation. Two and a half months after the onset of DIHS, subacute thyroiditis occurred, possibly associated with CMV reactivation. Prednisolone (20 mg/day) was effective for subacute thyroiditis. Long-term follow-up is needed in patients with DIHS because of the possible onset of autoimmune diseases. S. Karger AG 2015-07-24 /pmc/articles/PMC4560312/ /pubmed/26351424 http://dx.doi.org/10.1159/000437251 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Published online: July, 2015
Sato, Mika
Mizuno, Yuki
Matsuyama, Kanako
Shu, En
Kanoh, Hiroyuki
Suwa, Tetsuya
Seishima, Mariko
Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis
title Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis
title_full Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis
title_fullStr Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis
title_full_unstemmed Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis
title_short Drug-Induced Hypersensitivity Syndrome Followed by Subacute Thyroiditis
title_sort drug-induced hypersensitivity syndrome followed by subacute thyroiditis
topic Published online: July, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560312/
https://www.ncbi.nlm.nih.gov/pubmed/26351424
http://dx.doi.org/10.1159/000437251
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