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Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling

Abatacept is a biological immune modifier that is used for the treatment of rheumatoid arthritis. Although psoriasiform drug eruption is reported as one of the cutaneous adverse effects of abatacept, the precise mechanisms are not fully understood. In this report, we describe a 65-year-old Japanese...

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Autores principales: Tanita, Kayo, Fujimura, Taku, Kakizaki, Aya, Furudate, Sadanori, Kusakari, Yoshiyuki, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560327/
https://www.ncbi.nlm.nih.gov/pubmed/26351425
http://dx.doi.org/10.1159/000437415
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author Tanita, Kayo
Fujimura, Taku
Kakizaki, Aya
Furudate, Sadanori
Kusakari, Yoshiyuki
Aiba, Setsuya
author_facet Tanita, Kayo
Fujimura, Taku
Kakizaki, Aya
Furudate, Sadanori
Kusakari, Yoshiyuki
Aiba, Setsuya
author_sort Tanita, Kayo
collection PubMed
description Abatacept is a biological immune modifier that is used for the treatment of rheumatoid arthritis. Although psoriasiform drug eruption is reported as one of the cutaneous adverse effects of abatacept, the precise mechanisms are not fully understood. In this report, we describe a 65-year-old Japanese man with psoriasiform drug eruption caused by abatacept. Interestingly, immunohistochemical staining revealed that the epidermal keratinocytes in the basal layer and lower layers of the stratum spinosum were positive for pSTAT3, partially positive for pSTAT1 and negative for pSTAT6, which is similar to conventional psoriasis vulgaris. Our present study suggests that psoriasiform drug eruption caused by abatacept might develop by similar immunological mechanisms as those of psoriasis vulgaris.
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spelling pubmed-45603272015-09-08 Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling Tanita, Kayo Fujimura, Taku Kakizaki, Aya Furudate, Sadanori Kusakari, Yoshiyuki Aiba, Setsuya Case Rep Dermatol Published online: July, 2015 Abatacept is a biological immune modifier that is used for the treatment of rheumatoid arthritis. Although psoriasiform drug eruption is reported as one of the cutaneous adverse effects of abatacept, the precise mechanisms are not fully understood. In this report, we describe a 65-year-old Japanese man with psoriasiform drug eruption caused by abatacept. Interestingly, immunohistochemical staining revealed that the epidermal keratinocytes in the basal layer and lower layers of the stratum spinosum were positive for pSTAT3, partially positive for pSTAT1 and negative for pSTAT6, which is similar to conventional psoriasis vulgaris. Our present study suggests that psoriasiform drug eruption caused by abatacept might develop by similar immunological mechanisms as those of psoriasis vulgaris. S. Karger AG 2015-07-24 /pmc/articles/PMC4560327/ /pubmed/26351425 http://dx.doi.org/10.1159/000437415 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
spellingShingle Published online: July, 2015
Tanita, Kayo
Fujimura, Taku
Kakizaki, Aya
Furudate, Sadanori
Kusakari, Yoshiyuki
Aiba, Setsuya
Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling
title Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling
title_full Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling
title_fullStr Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling
title_full_unstemmed Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling
title_short Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling
title_sort psoriasiform drug eruption caused by abatacept: immunohistochemical investigation of stat signaling
topic Published online: July, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560327/
https://www.ncbi.nlm.nih.gov/pubmed/26351425
http://dx.doi.org/10.1159/000437415
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