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Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions
In simple organisms like E.coli, the metabolic response to an external perturbation passes through a transient phase in which the activation of a number of latent pathways can guarantee survival at the expenses of growth. Growth is gradually recovered as the organism adapts to the new condition. Thi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560427/ https://www.ncbi.nlm.nih.gov/pubmed/26340476 http://dx.doi.org/10.1371/journal.pcbi.1004434 |
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author | Altafini, Claudio Facchetti, Giuseppe |
author_facet | Altafini, Claudio Facchetti, Giuseppe |
author_sort | Altafini, Claudio |
collection | PubMed |
description | In simple organisms like E.coli, the metabolic response to an external perturbation passes through a transient phase in which the activation of a number of latent pathways can guarantee survival at the expenses of growth. Growth is gradually recovered as the organism adapts to the new condition. This adaptation can be modeled as a process of repeated metabolic adjustments obtained through the resilencings of the non-essential metabolic reactions, using growth rate as selection probability for the phenotypes obtained. The resulting metabolic adaptation process tends naturally to steer the metabolic fluxes towards high growth phenotypes. Quite remarkably, when applied to the central carbon metabolism of E.coli, it follows that nearly all flux distributions converge to the flux vector representing optimal growth, i.e., the solution of the biomass optimization problem turns out to be the dominant attractor of the metabolic adaptation process. |
format | Online Article Text |
id | pubmed-4560427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-45604272015-09-10 Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions Altafini, Claudio Facchetti, Giuseppe PLoS Comput Biol Research Article In simple organisms like E.coli, the metabolic response to an external perturbation passes through a transient phase in which the activation of a number of latent pathways can guarantee survival at the expenses of growth. Growth is gradually recovered as the organism adapts to the new condition. This adaptation can be modeled as a process of repeated metabolic adjustments obtained through the resilencings of the non-essential metabolic reactions, using growth rate as selection probability for the phenotypes obtained. The resulting metabolic adaptation process tends naturally to steer the metabolic fluxes towards high growth phenotypes. Quite remarkably, when applied to the central carbon metabolism of E.coli, it follows that nearly all flux distributions converge to the flux vector representing optimal growth, i.e., the solution of the biomass optimization problem turns out to be the dominant attractor of the metabolic adaptation process. Public Library of Science 2015-09-04 /pmc/articles/PMC4560427/ /pubmed/26340476 http://dx.doi.org/10.1371/journal.pcbi.1004434 Text en © 2015 Altafini, Facchetti http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Altafini, Claudio Facchetti, Giuseppe Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions |
title | Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions |
title_full | Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions |
title_fullStr | Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions |
title_full_unstemmed | Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions |
title_short | Metabolic Adaptation Processes That Converge to Optimal Biomass Flux Distributions |
title_sort | metabolic adaptation processes that converge to optimal biomass flux distributions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560427/ https://www.ncbi.nlm.nih.gov/pubmed/26340476 http://dx.doi.org/10.1371/journal.pcbi.1004434 |
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