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Osteoprotegerin-Mediated Homeostasis of Rank(+) Thymic Epithelial Cells Does Not Limit Foxp3(+) Regulatory T Cell Development

In the thymus, medullary thymic epithelial cells (mTEC) regulate T cell tolerance via negative selection and Foxp3(+) regulatory T cell (Treg) development, and alterations in the mTEC compartment can lead to tolerance breakdown and autoimmunity. Both the receptor activator for NF-κB (RANK)/RANK liga...

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Detalles Bibliográficos
Autores principales:	McCarthy, Nicholas I., Cowan, Jennifer E., Nakamura, Kyoko, Bacon, Andrea, Baik, Song, White, Andrea J., Parnell, Sonia M., Jenkinson, Eric J., Jenkinson, William E., Anderson, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2015
Materias:	Immune System Development
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560491/ https://www.ncbi.nlm.nih.gov/pubmed/26254339 http://dx.doi.org/10.4049/jimmunol.1501226

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