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Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids

BACKGROUND: Histologically, keloids contain excess fibroblasts and an overabundance of dermal collagen. Recently, it was reported that chymase induced a profibrotic response via transforming growth factor-β1 (TGF-β1)/Smad activation in keloid fibroblasts (KFs). However, the role of chymase in the lo...

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Detalles Bibliográficos
Autores principales:	Wang, Ru, Chen, Junjie, Zhang, Zhenyu, Cen, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560513/ https://www.ncbi.nlm.nih.gov/pubmed/26357464 http://dx.doi.org/10.2147/DDDT.S87842

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