The Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NAD

Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune responses. Recently, we found that Mtb utilizes the protein CpnT to kill human macrophages by secreting its C-terminal domain, named tuberculosis necrotizing toxin (TNT) that induces necrosis by an unknown mechanism....

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Detalles Bibliográficos
Autores principales: Sun, Jim, Siroy, Axel, Lokareddy, Ravi K., Speer, Alexander, Doornbos, Kathryn S., Cingolani, Gino, Niederweis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560639/
https://www.ncbi.nlm.nih.gov/pubmed/26237511
http://dx.doi.org/10.1038/nsmb.3064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560639/
https://www.ncbi.nlm.nih.gov/pubmed/26237511
http://dx.doi.org/10.1038/nsmb.3064

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