Cargando…

The Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NAD

Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune responses. Recently, we found that Mtb utilizes the protein CpnT to kill human macrophages by secreting its C-terminal domain, named tuberculosis necrotizing toxin (TNT) that induces necrosis by an unknown mechanism....

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Jim, Siroy, Axel, Lokareddy, Ravi K., Speer, Alexander, Doornbos, Kathryn S., Cingolani, Gino, Niederweis, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560639/ https://www.ncbi.nlm.nih.gov/pubmed/26237511 http://dx.doi.org/10.1038/nsmb.3064

Ejemplares similares

The tuberculosis necrotizing toxin is an NAD(+) and NADP(+) glycohydrolase with distinct enzymatic properties
por: Tak, Uday, et al.
Publicado: (2019)

Expression and purification of phage T7 ejection proteins for cryo-EM analysis
por: Swanson, Nicholas A., et al.
Publicado: (2021)

Heme and hemoglobin utilization by Mycobacterium tuberculosis
por: Mitra, Avishek, et al.
Publicado: (2019)

Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase
por: Sankhala, Rajeshwer Singh, et al.
Publicado: (2014)

Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis
por: Wells, Ryan M., et al.
Publicado: (2013)

Viral Small Terminase: A Divergent Structural Framework for a Conserved Biological Function
por: Lokareddy, Ravi K., et al.
Publicado: (2022)

Toxin secretion and trafficking by Mycobacterium tuberculosis
por: Pajuelo, David, et al.
Publicado: (2021)

Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
por: Tak, Uday, et al.
Publicado: (2021)

An NAD(+) Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death
por: Freire, Diana Mendes, et al.
Publicado: (2019)

Protein Phosphatase, Mg(2+)/Mn(2+)-dependent 1A controls the innate antiviral and antibacterial response of macrophages during HIV-1 and Mycobacterium tuberculosis infection
por: Sun, Jim, et al.
Publicado: (2016)

Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
por: Sankhala, Rajeshwer S., et al.
Publicado: (2017)

Streptolysin O and its Co-Toxin NAD-glycohydrolase Protect Group A Streptococcus from Xenophagic Killing
por: O'Seaghdha, Maghnus, et al.
Publicado: (2013)

High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217
por: Li, Fenglin, et al.
Publicado: (2023)

Entry and Killing of Tetrahymena thermophila by Bacterially Produced Shiga Toxin
por: Stolfa, Gino, et al.
Publicado: (2012)

PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis
por: Mitra, Avishek, et al.
Publicado: (2017)

Biophysical analysis of Pseudomonas-phage PaP3 small terminase suggests a mechanism for sequence-specific DNA-binding by lateral interdigitation
por: Niazi, Marzia, et al.
Publicado: (2020)

Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms
por: Wu, Wei, et al.
Publicado: (2017)

A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly
por: Motwani, Tina, et al.
Publicado: (2017)

Differential recognition of canonical NF-κB dimers by Importin α3
por: Florio, Tyler J., et al.
Publicado: (2022)

Mycobacterium tuberculosis replicates within necrotic human macrophages
por: Lerner, Thomas R., et al.
Publicado: (2017)

Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation
por: Lokareddy, Ravi K., et al.
Publicado: (2017)

Conservation of inner nuclear membrane targeting sequences in mammalian Pom121 and yeast Heh2 membrane proteins
por: Kralt, Annemarie, et al.
Publicado: (2015)

The p53-induced factor Ei24 inhibits nuclear import through an importin β–binding–like domain
por: Lieu, Kim G., et al.
Publicado: (2014)

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis
por: Sharma, Ritu, et al.
Publicado: (2023)

Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis
por: Hawerkamp, Heike C., et al.
Publicado: (2020)

Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates
por: Toniolo, Chiara, et al.
Publicado: (2023)

The Effect of Nicotinamide Riboside, an NAD + Precursor, on Glycolysis and NAD + Salvage Pathway in Alcohol-Stimulated Macrophages
por: Kang, Hyunju, et al.
Publicado: (2022)

A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis
por: Zhang, Lei, et al.
Publicado: (2022)

Structural basis for the homotypic fusion of chlamydial inclusions by the SNARE-like protein IncA
por: Cingolani, Gino, et al.
Publicado: (2019)

Fatal necrotizing fasciitis due to necrotic toxin-producing Escherichia coli strain
por: Gallois, C., et al.
Publicado: (2015)

Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo
por: Scobie, Heather M, et al.
Publicado: (2006)

Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis
por: Ó Maoldomhnaigh, Cilian, et al.
Publicado: (2021)

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
por: Rogers, Corey, et al.
Publicado: (2017)

Recognition of the TDP-43 nuclear localization signal by importin α1/β
por: Doll, Steven G., et al.
Publicado: (2022)

Correction: Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo
por: Scobie, Heather M, et al.
Publicado: (2008)

Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages
Publicado: (1992)

TLR4-NOX2 axis regulates the phagocytosis and killing of Mycobacterium tuberculosis by macrophages
por: Lv, Jingzhu, et al.
Publicado: (2017)

Retraining macrophages to kill tumors
por: Bashyam, Hema
Publicado: (2008)

Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing
por: Marreddy, Ravi K. R., et al.
Publicado: (2021)

Selective killing of K-ras–transformed pancreatic cancer cells by targeting NAD(P)H oxidase
por: Wang, Peng, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_0invc38qm419sm5m0pi7bo11fj