A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity

Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we show that loss of PTEN in epithelial and melanocytic cell lines induces the nuclear localiza...

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Detalles Bibliográficos
Autores principales: Conde-Perez, Alejandro, Gros, Gwendoline, Longvert, Christine, Pedersen, Malin, Petit, Valérie, Aktary, Zackie, Viros, Amaya, Gesbert, Franck, Delmas, Véronique, Rambow, Florian, Bastian, Boris C., Campbell, Andrew D., Colombo, Sophie, Puig, Isabel, Bellacosa, Alfonso, Sansom, Owen, Marais, Richard, Van Kempen, Leon C. L. T., Larue, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560817/
https://www.ncbi.nlm.nih.gov/pubmed/26307673
http://dx.doi.org/10.1038/ncomms9093

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