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NUT expression in primary lung tumours

BACKGROUND: Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there...

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Autores principales: Lund-Iversen, Marius, Grøholt, Krystyna Kotanska, Helland, Åslaug, Borgen, Elin, Brustugun, Odd Terje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560868/
https://www.ncbi.nlm.nih.gov/pubmed/26341600
http://dx.doi.org/10.1186/s13000-015-0395-9
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author Lund-Iversen, Marius
Grøholt, Krystyna Kotanska
Helland, Åslaug
Borgen, Elin
Brustugun, Odd Terje
author_facet Lund-Iversen, Marius
Grøholt, Krystyna Kotanska
Helland, Åslaug
Borgen, Elin
Brustugun, Odd Terje
author_sort Lund-Iversen, Marius
collection PubMed
description BACKGROUND: Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding occurrence in structures outside the midline. We investigated specimens from 519 surgically resected lung carcinomas and carcinoid tumours for the presence of NUT protein using immunohistochemistry. Normal testis and two previously confirmed NMCs served as positive controls. FINDINGS: All 483 evaluable cases (278 adenocarcinomas, 140 squamous cell carcinomas, 30 large cell carcinomas, 7 small cell carcinomas, 10 undifferentiated carcinomas and 18 carcinoids) were completely negative for expression of NUT protein. CONCLUSION: NUT gene rearrangement does not seem to be relevant in primary pulmonary carcinomas or carcinoid tumours of the lung.
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spelling pubmed-45608682015-09-06 NUT expression in primary lung tumours Lund-Iversen, Marius Grøholt, Krystyna Kotanska Helland, Åslaug Borgen, Elin Brustugun, Odd Terje Diagn Pathol Short Report BACKGROUND: Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding occurrence in structures outside the midline. We investigated specimens from 519 surgically resected lung carcinomas and carcinoid tumours for the presence of NUT protein using immunohistochemistry. Normal testis and two previously confirmed NMCs served as positive controls. FINDINGS: All 483 evaluable cases (278 adenocarcinomas, 140 squamous cell carcinomas, 30 large cell carcinomas, 7 small cell carcinomas, 10 undifferentiated carcinomas and 18 carcinoids) were completely negative for expression of NUT protein. CONCLUSION: NUT gene rearrangement does not seem to be relevant in primary pulmonary carcinomas or carcinoid tumours of the lung. BioMed Central 2015-09-05 /pmc/articles/PMC4560868/ /pubmed/26341600 http://dx.doi.org/10.1186/s13000-015-0395-9 Text en © Lund-Iversen et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Lund-Iversen, Marius
Grøholt, Krystyna Kotanska
Helland, Åslaug
Borgen, Elin
Brustugun, Odd Terje
NUT expression in primary lung tumours
title NUT expression in primary lung tumours
title_full NUT expression in primary lung tumours
title_fullStr NUT expression in primary lung tumours
title_full_unstemmed NUT expression in primary lung tumours
title_short NUT expression in primary lung tumours
title_sort nut expression in primary lung tumours
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560868/
https://www.ncbi.nlm.nih.gov/pubmed/26341600
http://dx.doi.org/10.1186/s13000-015-0395-9
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