High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis

BACKGROUND: Schistosomiasis, a parasitic disease also known as bilharzia and snail fever, is caused by different species of flatworms, such as Schistosoma mansoni (S. mansoni). Thioredoxin glutathione reductase (TGR) from S. mansoni (SmTGR) is a well-characterized drug target for schistosomiasis, ye...

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Detalles Bibliográficos
Autores principales: Li, Ting, Ziniel, Peter D., He, Pan-qing, Kommer, Valerie P., Crowther, Gregory J., He, Min, Liu, Qing, Van Voorhis, Wesley C., Williams, David L., Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560900/
https://www.ncbi.nlm.nih.gov/pubmed/26341081
http://dx.doi.org/10.1186/s40249-015-0071-z

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