Molecular Insight in the Multifunctional Effects of Oridonin

Oridonin has attracted considerable attention in the last decade because of its anti-cancer pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb Rabdosia rubescens and some related species, has demonstrated great potential in the treatment profile of many diseases...

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Detalles Bibliográficos
Autores principales: Owona, Brice Ayissi, Schluesener, Herman J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561052/
https://www.ncbi.nlm.nih.gov/pubmed/26290464
http://dx.doi.org/10.1007/s40268-015-0102-z
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author Owona, Brice Ayissi
Schluesener, Herman J.
author_facet Owona, Brice Ayissi
Schluesener, Herman J.
author_sort Owona, Brice Ayissi
collection PubMed
description Oridonin has attracted considerable attention in the last decade because of its anti-cancer pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb Rabdosia rubescens and some related species, has demonstrated great potential in the treatment profile of many diseases by exerting anti-tumor, anti-inflammatory, pro-apoptotic, and neurological effects. Unfortunately, the mechanisms via which oridonin exerts these effects remain poorly understood. This review provides an overview of the multifunctional effects of oridonin as well as the reasons for its potential for investigations in the treatment of many diseases other than cancer.
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spelling pubmed-45610522015-09-11 Molecular Insight in the Multifunctional Effects of Oridonin Owona, Brice Ayissi Schluesener, Herman J. Drugs R D Review Article Oridonin has attracted considerable attention in the last decade because of its anti-cancer pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb Rabdosia rubescens and some related species, has demonstrated great potential in the treatment profile of many diseases by exerting anti-tumor, anti-inflammatory, pro-apoptotic, and neurological effects. Unfortunately, the mechanisms via which oridonin exerts these effects remain poorly understood. This review provides an overview of the multifunctional effects of oridonin as well as the reasons for its potential for investigations in the treatment of many diseases other than cancer. Springer International Publishing 2015-08-20 2015-09 /pmc/articles/PMC4561052/ /pubmed/26290464 http://dx.doi.org/10.1007/s40268-015-0102-z Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Owona, Brice Ayissi
Schluesener, Herman J.
Molecular Insight in the Multifunctional Effects of Oridonin
title Molecular Insight in the Multifunctional Effects of Oridonin
title_full Molecular Insight in the Multifunctional Effects of Oridonin
title_fullStr Molecular Insight in the Multifunctional Effects of Oridonin
title_full_unstemmed Molecular Insight in the Multifunctional Effects of Oridonin
title_short Molecular Insight in the Multifunctional Effects of Oridonin
title_sort molecular insight in the multifunctional effects of oridonin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561052/
https://www.ncbi.nlm.nih.gov/pubmed/26290464
http://dx.doi.org/10.1007/s40268-015-0102-z
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