Lentivirus-induced ‘Smart' dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma

Monocyte-derived conventional dendritic cells (ConvDCs) loaded with melanoma antigens showed modest responses in clinical trials. Efficacy studies were hampered by difficulties in ConvDC manufacturing and low potency. Overcoming these issues, we demonstrated higher potency of lentiviral vector (LV)-...

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Detalles Bibliográficos
Autores principales: Sundarasetty, B S, Chan, L, Darling, D, Giunti, G, Farzaneh, F, Schenck, F, Naundorf, S, Kuehlcke, K, Ruggiero, E, Schmidt, M, von Kalle, C, Rothe, M, Hoon, D S B, Gerasch, L, Figueiredo, C, Koehl, U, Blasczyk, R, Gutzmer, R, Stripecke, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561294/
https://www.ncbi.nlm.nih.gov/pubmed/25965393
http://dx.doi.org/10.1038/gt.2015.43

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