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Effects of Tongmai oral liquid in femoral ateriovenous fistula

BACKGROUND: This study was conducted to investigate the protective effect of Tongmai oral liquid on arteriovenous fistula function and to provide an effective method to promote fistula maturation. METHODS: Fifteen female and fifteen male SPF New Zealand rabbits were randomly allocated into 3 groups...

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Autores principales: Su, Pei-Ling, Bao, Kun, Peng, Han-Guo, Mao, Wei, Wang, Guan-Su, Yang, Ni-Zhi, Geng, Wen-Jia, Lin, Yi-Qun, Jie, Xi-Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561428/
https://www.ncbi.nlm.nih.gov/pubmed/26347072
http://dx.doi.org/10.1186/s12906-015-0844-8
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author Su, Pei-Ling
Bao, Kun
Peng, Han-Guo
Mao, Wei
Wang, Guan-Su
Yang, Ni-Zhi
Geng, Wen-Jia
Lin, Yi-Qun
Jie, Xi-Na
author_facet Su, Pei-Ling
Bao, Kun
Peng, Han-Guo
Mao, Wei
Wang, Guan-Su
Yang, Ni-Zhi
Geng, Wen-Jia
Lin, Yi-Qun
Jie, Xi-Na
author_sort Su, Pei-Ling
collection PubMed
description BACKGROUND: This study was conducted to investigate the protective effect of Tongmai oral liquid on arteriovenous fistula function and to provide an effective method to promote fistula maturation. METHODS: Fifteen female and fifteen male SPF New Zealand rabbits were randomly allocated into 3 groups including control, Aspirin and Tongmai oral liquid groups. A side-to-side femoral arteriovenous fistula was established in each rabbit and then animals were treated with Aspirin or Tongmai oral liquid for 2 weeks. The concentrations of circulating ET-1 and NO were determined before and after operation (on preoperative day, operative day, post-D1, post-D3, post-D7 and post-D15), respectively. Blood flow of the fistula stoma and contralateral artery and vein was determined on the 15(th) postoperative day. Last, the fistula stoma was dissected to observe patency, thrombosis and adhesion with surrounding tissues. RESULTS: 28 rabbits survived during the surgical process and the following 15-day observational period. Tissue adhesion of arteriovenous fistula with surrounding tissues was improved and fistula thrombosis was reduced by treatment with Tongmai oral liquid. NO concentration decreased to a different extent after vascular surgery. Tongmai oral liquid failed to regulate the equilibrium between NO and ET-1, but it improved blood flow of fistula stoma, as compared to control and Aspirin groups. Blood flow of fistula stoma in the three groups was lower than that of the contralateral femoral artery. CONCLUSIONS: Tongmai oral liquid improved the function of femoral ateriovenous fistula in the rabbit model by increasing blood flow and reducing thrombosis, probably not by regulating the dynamic equilibrium between NO and ET-1.
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spelling pubmed-45614282015-09-08 Effects of Tongmai oral liquid in femoral ateriovenous fistula Su, Pei-Ling Bao, Kun Peng, Han-Guo Mao, Wei Wang, Guan-Su Yang, Ni-Zhi Geng, Wen-Jia Lin, Yi-Qun Jie, Xi-Na BMC Complement Altern Med Research Article BACKGROUND: This study was conducted to investigate the protective effect of Tongmai oral liquid on arteriovenous fistula function and to provide an effective method to promote fistula maturation. METHODS: Fifteen female and fifteen male SPF New Zealand rabbits were randomly allocated into 3 groups including control, Aspirin and Tongmai oral liquid groups. A side-to-side femoral arteriovenous fistula was established in each rabbit and then animals were treated with Aspirin or Tongmai oral liquid for 2 weeks. The concentrations of circulating ET-1 and NO were determined before and after operation (on preoperative day, operative day, post-D1, post-D3, post-D7 and post-D15), respectively. Blood flow of the fistula stoma and contralateral artery and vein was determined on the 15(th) postoperative day. Last, the fistula stoma was dissected to observe patency, thrombosis and adhesion with surrounding tissues. RESULTS: 28 rabbits survived during the surgical process and the following 15-day observational period. Tissue adhesion of arteriovenous fistula with surrounding tissues was improved and fistula thrombosis was reduced by treatment with Tongmai oral liquid. NO concentration decreased to a different extent after vascular surgery. Tongmai oral liquid failed to regulate the equilibrium between NO and ET-1, but it improved blood flow of fistula stoma, as compared to control and Aspirin groups. Blood flow of fistula stoma in the three groups was lower than that of the contralateral femoral artery. CONCLUSIONS: Tongmai oral liquid improved the function of femoral ateriovenous fistula in the rabbit model by increasing blood flow and reducing thrombosis, probably not by regulating the dynamic equilibrium between NO and ET-1. BioMed Central 2015-09-07 /pmc/articles/PMC4561428/ /pubmed/26347072 http://dx.doi.org/10.1186/s12906-015-0844-8 Text en © Su et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Su, Pei-Ling
Bao, Kun
Peng, Han-Guo
Mao, Wei
Wang, Guan-Su
Yang, Ni-Zhi
Geng, Wen-Jia
Lin, Yi-Qun
Jie, Xi-Na
Effects of Tongmai oral liquid in femoral ateriovenous fistula
title Effects of Tongmai oral liquid in femoral ateriovenous fistula
title_full Effects of Tongmai oral liquid in femoral ateriovenous fistula
title_fullStr Effects of Tongmai oral liquid in femoral ateriovenous fistula
title_full_unstemmed Effects of Tongmai oral liquid in femoral ateriovenous fistula
title_short Effects of Tongmai oral liquid in femoral ateriovenous fistula
title_sort effects of tongmai oral liquid in femoral ateriovenous fistula
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561428/
https://www.ncbi.nlm.nih.gov/pubmed/26347072
http://dx.doi.org/10.1186/s12906-015-0844-8
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