Sequential replication-coupled destruction at G1/S ensures genome stability

Timely ubiquitin-mediated protein degradation is fundamental to cell cycle control, but the precise degradation order at each cell cycle phase transition is still unclear. We investigated the degradation order among substrates of a single human E3 ubiquitin ligase, CRL4(Cdt2), which mediates the S-p...

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Detalles Bibliográficos
Autores principales: Coleman, Kate E., Grant, Gavin D., Haggerty, Rachel A., Brantley, Kristen, Shibata, Etsuko, Workman, Benjamin D., Dutta, Anindya, Varma, Dileep, Purvis, Jeremy E., Cook, Jeanette Gowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561482/
https://www.ncbi.nlm.nih.gov/pubmed/26272819
http://dx.doi.org/10.1101/gad.263731.115

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