piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire

PIWI clade Argonaute proteins silence transposon expression in animal gonads. Their target specificity is defined by bound ∼23- to 30-nucleotide (nt) PIWI-interacting RNAs (piRNAs) that are processed from single-stranded precursor transcripts via two distinct pathways. Primary piRNAs are defined by...

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Detalles Bibliográficos
Autores principales: Senti, Kirsten-André, Jurczak, Daniel, Sachidanandam, Ravi, Brennecke, Julius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561483/
https://www.ncbi.nlm.nih.gov/pubmed/26302790
http://dx.doi.org/10.1101/gad.267252.115

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