Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization

Selenoproteins are proteins that incorporate selenocysteine (Sec), a nonstandard amino acid encoded by UGA, normally a stop codon. Sec synthesis requires the enzyme Selenophosphate synthetase (SPS or SelD), conserved in all prokaryotic and eukaryotic genomes encoding selenoproteins. Here, we study t...

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Detalles Bibliográficos
Autores principales: Mariotti, Marco, Santesmasses, Didac, Capella-Gutierrez, Salvador, Mateo, Andrea, Arnan, Carme, Johnson, Rory, D'Aniello, Salvatore, Yim, Sun Hee, Gladyshev, Vadim N., Serras, Florenci, Corominas, Montserrat, Gabaldón, Toni, Guigó, Roderic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561486/
https://www.ncbi.nlm.nih.gov/pubmed/26194102
http://dx.doi.org/10.1101/gr.190538.115

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