Discriminating somatic and germline mutations in tumor DNA samples without matching normals

Tumor analyses commonly employ a correction with a matched normal (MN), a sample from healthy tissue of the same individual, in order to distinguish germline mutations from somatic mutations. Since the majority of variants found in an individual are thought to be common within the population, we con...

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Detalles Bibliográficos
Autores principales: Hiltemann, Saskia, Jenster, Guido, Trapman, Jan, van der Spek, Peter, Stubbs, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561496/
https://www.ncbi.nlm.nih.gov/pubmed/26209359
http://dx.doi.org/10.1101/gr.183053.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561496/
https://www.ncbi.nlm.nih.gov/pubmed/26209359
http://dx.doi.org/10.1101/gr.183053.114

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