Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA

One possible treatment for Huntington's disease involves direct infusion of a small, interfering RNA (siRNA) designed to reduce huntingtin expression into brain tissue from a chronically implanted programmable pump. Here, we studied the suppression of huntingtin mRNA achievable with short infus...

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Detalles Bibliográficos
Autores principales: Grondin, Richard, Ge, Pei, Chen, Qingmin, Sutherland, Jessica E., Zhang, Zhiming, Gash, Don M, Stiles, David K, Stewart, Gregory R, Sah, Dinah W Y, Kaemmerer, William F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561652/
https://www.ncbi.nlm.nih.gov/pubmed/26125484
http://dx.doi.org/10.1038/mtna.2015.20

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