Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors

MicroRNAs regulate eukaryotic gene expression upon pairing onto target mRNAs. This targeting is influenced by the complementarity between the microRNA “seed” sequence at its 5′ end and the seed-matching sequences in the mRNA. Here, we assess the efficiency and specificity of 8-mer locked nucleic aci...

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Detalles Bibliográficos
Autores principales: Staedel, Cathy, Varon, Christine, Nguyen, Phu Hung, Vialet, Brune, Chambonnier, Lucie, Rousseau, Benoît, Soubeyran, Isabelle, Evrard, Serge, Couillaud, Franck, Darfeuille, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561653/
https://www.ncbi.nlm.nih.gov/pubmed/26151747
http://dx.doi.org/10.1038/mtna.2015.18

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