Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Loss of the RNA-binding protein Bicaudal-C (Bicc1) provokes renal and pancreatic cysts as well as ectopic Wnt/β-catenin signaling during visceral left-right patterning. Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including adenylate cyclase 6 (AC6). RNA binding of Bicc1 is m...

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Detalles Bibliográficos
Autores principales: Rothé, Benjamin, Leal-Esteban, Lucia, Bernet, Florian, Urfer, Séverine, Doerr, Nicholas, Weimbs, Thomas, Iwaszkiewicz, Justyna, Constam, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561730/
https://www.ncbi.nlm.nih.gov/pubmed/26217012
http://dx.doi.org/10.1128/MCB.00341-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561730/
https://www.ncbi.nlm.nih.gov/pubmed/26217012
http://dx.doi.org/10.1128/MCB.00341-15

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