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Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer

Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling. However, in the case of miR-19a...

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Detalles Bibliográficos
Autores principales: Fuziwara, Cesar Seigi, Kimura, Edna Teruko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561802/
https://www.ncbi.nlm.nih.gov/pubmed/26442266
http://dx.doi.org/10.3389/fmed.2015.00064
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author Fuziwara, Cesar Seigi
Kimura, Edna Teruko
author_facet Fuziwara, Cesar Seigi
Kimura, Edna Teruko
author_sort Fuziwara, Cesar Seigi
collection PubMed
description Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the cluster’s oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer.
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spelling pubmed-45618022015-10-05 Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer Fuziwara, Cesar Seigi Kimura, Edna Teruko Front Med (Lausanne) Medicine Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the cluster’s oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer. Frontiers Media S.A. 2015-09-08 /pmc/articles/PMC4561802/ /pubmed/26442266 http://dx.doi.org/10.3389/fmed.2015.00064 Text en Copyright © 2015 Fuziwara and Kimura. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Fuziwara, Cesar Seigi
Kimura, Edna Teruko
Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer
title Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer
title_full Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer
title_fullStr Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer
title_full_unstemmed Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer
title_short Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer
title_sort insights into regulation of the mir-17-92 cluster of mirnas in cancer
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561802/
https://www.ncbi.nlm.nih.gov/pubmed/26442266
http://dx.doi.org/10.3389/fmed.2015.00064
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