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Disease Related Knowledge Summarization Based on Deep Graph Search

The volume of published biomedical literature on disease related knowledge is expanding rapidly. Traditional information retrieval (IR) techniques, when applied to large databases such as PubMed, often return large, unmanageable lists of citations that do not fulfill the searcher's information...

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Detalles Bibliográficos
Autores principales: Wu, Xiaofang, Yang, Zhihao, Li, ZhiHeng, Lin, Hongfei, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561941/
https://www.ncbi.nlm.nih.gov/pubmed/26413521
http://dx.doi.org/10.1155/2015/428195
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author Wu, Xiaofang
Yang, Zhihao
Li, ZhiHeng
Lin, Hongfei
Wang, Jian
author_facet Wu, Xiaofang
Yang, Zhihao
Li, ZhiHeng
Lin, Hongfei
Wang, Jian
author_sort Wu, Xiaofang
collection PubMed
description The volume of published biomedical literature on disease related knowledge is expanding rapidly. Traditional information retrieval (IR) techniques, when applied to large databases such as PubMed, often return large, unmanageable lists of citations that do not fulfill the searcher's information needs. In this paper, we present an approach to automatically construct disease related knowledge summarization from biomedical literature. In this approach, firstly Kullback-Leibler Divergence combined with mutual information metric is used to extract disease salient information. Then deep search based on depth first search (DFS) is applied to find hidden (indirect) relations between biomedical entities. Finally random walk algorithm is exploited to filter out the weak relations. The experimental results show that our approach achieves a precision of 60% and a recall of 61% on salient information extraction for Carcinoma of bladder and outperforms the method of Combo.
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spelling pubmed-45619412015-09-27 Disease Related Knowledge Summarization Based on Deep Graph Search Wu, Xiaofang Yang, Zhihao Li, ZhiHeng Lin, Hongfei Wang, Jian Biomed Res Int Research Article The volume of published biomedical literature on disease related knowledge is expanding rapidly. Traditional information retrieval (IR) techniques, when applied to large databases such as PubMed, often return large, unmanageable lists of citations that do not fulfill the searcher's information needs. In this paper, we present an approach to automatically construct disease related knowledge summarization from biomedical literature. In this approach, firstly Kullback-Leibler Divergence combined with mutual information metric is used to extract disease salient information. Then deep search based on depth first search (DFS) is applied to find hidden (indirect) relations between biomedical entities. Finally random walk algorithm is exploited to filter out the weak relations. The experimental results show that our approach achieves a precision of 60% and a recall of 61% on salient information extraction for Carcinoma of bladder and outperforms the method of Combo. Hindawi Publishing Corporation 2015 2015-08-25 /pmc/articles/PMC4561941/ /pubmed/26413521 http://dx.doi.org/10.1155/2015/428195 Text en Copyright © 2015 Xiaofang Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Xiaofang
Yang, Zhihao
Li, ZhiHeng
Lin, Hongfei
Wang, Jian
Disease Related Knowledge Summarization Based on Deep Graph Search
title Disease Related Knowledge Summarization Based on Deep Graph Search
title_full Disease Related Knowledge Summarization Based on Deep Graph Search
title_fullStr Disease Related Knowledge Summarization Based on Deep Graph Search
title_full_unstemmed Disease Related Knowledge Summarization Based on Deep Graph Search
title_short Disease Related Knowledge Summarization Based on Deep Graph Search
title_sort disease related knowledge summarization based on deep graph search
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561941/
https://www.ncbi.nlm.nih.gov/pubmed/26413521
http://dx.doi.org/10.1155/2015/428195
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