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Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?
Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of ove...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561987/ https://www.ncbi.nlm.nih.gov/pubmed/26380121 http://dx.doi.org/10.1155/2015/759139 |
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author | Köhler, Cristiano A. Carvalho, André F. Alves, Gilberto S. McIntyre, Roger S. Hyphantis, Thomas N. Cammarota, Martín |
author_facet | Köhler, Cristiano A. Carvalho, André F. Alves, Gilberto S. McIntyre, Roger S. Hyphantis, Thomas N. Cammarota, Martín |
author_sort | Köhler, Cristiano A. |
collection | PubMed |
description | Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of overgeneral memories in detriment of specific autobiographical memories; and the role of ruminative processes and avoidance when dealing with autobiographical memories. Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals. Disruptions in autobiographical memories predispose and portend onset and maintenance of depression. Thus, we discuss emerging therapeutics that target memory difficulties in those with depression. We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression. We propose that the manipulation of the reconsolidation of autobiographical memories in depression might represent a novel yet largely unexplored, domain-specific, therapeutic opportunity for depression treatment. |
format | Online Article Text |
id | pubmed-4561987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45619872015-09-15 Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? Köhler, Cristiano A. Carvalho, André F. Alves, Gilberto S. McIntyre, Roger S. Hyphantis, Thomas N. Cammarota, Martín Neural Plast Review Article Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories. We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of overgeneral memories in detriment of specific autobiographical memories; and the role of ruminative processes and avoidance when dealing with autobiographical memories. Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals. Disruptions in autobiographical memories predispose and portend onset and maintenance of depression. Thus, we discuss emerging therapeutics that target memory difficulties in those with depression. We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression. We propose that the manipulation of the reconsolidation of autobiographical memories in depression might represent a novel yet largely unexplored, domain-specific, therapeutic opportunity for depression treatment. Hindawi Publishing Corporation 2015 2015-08-25 /pmc/articles/PMC4561987/ /pubmed/26380121 http://dx.doi.org/10.1155/2015/759139 Text en Copyright © 2015 Cristiano A. Köhler et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Köhler, Cristiano A. Carvalho, André F. Alves, Gilberto S. McIntyre, Roger S. Hyphantis, Thomas N. Cammarota, Martín Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
title | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
title_full | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
title_fullStr | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
title_full_unstemmed | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
title_short | Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target? |
title_sort | autobiographical memory disturbances in depression: a novel therapeutic target? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561987/ https://www.ncbi.nlm.nih.gov/pubmed/26380121 http://dx.doi.org/10.1155/2015/759139 |
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