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Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

BACKGROUND: The pathological hallmarks of Parkinson’s disease are intracellular inclusions composed mainly of misfolded α-synuclein (αSYN). Under physiological conditions αSYN is mostly localized in synapses. In addition, a portion of αSYN is secreted to the extracellular space, where it may be sequ...

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Detalles Bibliográficos
Autores principales:	Rannikko, Emmy H., Weber, Stephanie S., Kahle, Philipp J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562100/ https://www.ncbi.nlm.nih.gov/pubmed/26346361 http://dx.doi.org/10.1186/s12868-015-0192-0

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