Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage

BACKGROUND: Genetic recombination plays an important role in evolution, facilitating the creation of new, favorable combinations of alleles and the removal of deleterious mutations by unlinking them from surrounding sequences. In most mammals, the placement of genetic crossovers is determined by the...

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Detalles Bibliográficos
Autores principales: Walker, Michael, Billings, Timothy, Baker, Christopher L., Powers, Natalie, Tian, Hui, Saxl, Ruth L., Choi, Kwangbom, Hibbs, Matthew A., Carter, Gregory W., Handel, Mary Ann, Paigen, Kenneth, Petkov, Petko M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562113/
https://www.ncbi.nlm.nih.gov/pubmed/26351520
http://dx.doi.org/10.1186/s13072-015-0024-6

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