Cargando…

An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine

Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR) and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to “anti-c” ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Sachan, Deepti, Jayakumar, Rajeswari, Varghese, Joy, Rela, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562150/
https://www.ncbi.nlm.nih.gov/pubmed/26420949
http://dx.doi.org/10.4103/0973-6247.154256
Descripción
Sumario:Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR) and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to “anti-c” antibodies within 3 h of blood transfusion, precipitating fatal acute liver failure in a patient with hepatitis C related chronic liver disease. This case emphasizes the need of inclusion of antibody screening in routine pretransfusion testing as well as a critical role of transfusion medicine specialists for early diagnosis and minimizing transfusion-related morbidity and mortality.