An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine

Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR) and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to “anti-c” ant...

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Autores principales: Sachan, Deepti, Jayakumar, Rajeswari, Varghese, Joy, Rela, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562150/
https://www.ncbi.nlm.nih.gov/pubmed/26420949
http://dx.doi.org/10.4103/0973-6247.154256
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author Sachan, Deepti
Jayakumar, Rajeswari
Varghese, Joy
Rela, Mohamed
author_facet Sachan, Deepti
Jayakumar, Rajeswari
Varghese, Joy
Rela, Mohamed
author_sort Sachan, Deepti
collection PubMed
description Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR) and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to “anti-c” antibodies within 3 h of blood transfusion, precipitating fatal acute liver failure in a patient with hepatitis C related chronic liver disease. This case emphasizes the need of inclusion of antibody screening in routine pretransfusion testing as well as a critical role of transfusion medicine specialists for early diagnosis and minimizing transfusion-related morbidity and mortality.
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spelling pubmed-45621502015-09-29 An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine Sachan, Deepti Jayakumar, Rajeswari Varghese, Joy Rela, Mohamed Asian J Transfus Sci Case Report Rhesus (Rh) mediated hemolytic transfusion reactions (HTR) are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR) and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to “anti-c” antibodies within 3 h of blood transfusion, precipitating fatal acute liver failure in a patient with hepatitis C related chronic liver disease. This case emphasizes the need of inclusion of antibody screening in routine pretransfusion testing as well as a critical role of transfusion medicine specialists for early diagnosis and minimizing transfusion-related morbidity and mortality. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4562150/ /pubmed/26420949 http://dx.doi.org/10.4103/0973-6247.154256 Text en Copyright: © Asian Journal of Transfusion Science http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sachan, Deepti
Jayakumar, Rajeswari
Varghese, Joy
Rela, Mohamed
An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine
title An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine
title_full An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine
title_fullStr An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine
title_full_unstemmed An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine
title_short An acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: A case report emphasizing the role of transfusion medicine
title_sort acute hemolytic transfusion reaction due to the “anti-c” rhesus antibody: a case report emphasizing the role of transfusion medicine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562150/
https://www.ncbi.nlm.nih.gov/pubmed/26420949
http://dx.doi.org/10.4103/0973-6247.154256
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