Cargando…

Analysis of “On/Off” Kinetics of a CETP Inhibitor Using a Mechanistic Model of Lipoprotein Metabolism and Kinetics

RG7232 is a potent inhibitor of cholesteryl-ester transfer protein (CETP). Daily oral administration of RG7232 produces a dose- and time-dependent increase in high-density lipoprotein-cholesterol (HDL-C) and apolipoproteinA-I (ApoA-I) levels and a corresponding decrease in low-density lipoprotein-ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, J, Cleary, Y, Maugeais, C, Kiu Weber, CI, Mazer, NA
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562162/ https://www.ncbi.nlm.nih.gov/pubmed/26380155 http://dx.doi.org/10.1002/psp4.27

Ejemplares similares

An In-Silico Model of Lipoprotein Metabolism and Kinetics for the Evaluation of Targets and Biomarkers in the Reverse Cholesterol Transport Pathway
por: Lu, James, et al.
Publicado: (2014)

Cholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors
por: Mabuchi, Hiroshi, et al.
Publicado: (2014)

Dose Effects of Ammonium Perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP Mice
por: Pouwer, Marianne G, et al.
Publicado: (2019)

Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans
por: Adiels, Martin, et al.
Publicado: (2015)

A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation
por: Tang, Peifeng, et al.
Publicado: (2017)

Regulatory Effects of Fenofibrate and Atorvastatin on Lipoprotein A-I and Lipoprotein A-I:A-II Kinetics in the Metabolic Syndrome
por: Chan, Dick C., et al.
Publicado: (2009)

CETP inhibitors and cardiovascular disease: Time to think again
por: Miller, Norman E
Publicado: (2014)

CETP inhibitor evacetrapib enters mouse brain tissue
por: Phénix, Jasmine, et al.
Publicado: (2023)

H/D Exchange Processes in Flavonoids: Kinetics and Mechanistic Investigations
por: Bonaldo, Federico, et al.
Publicado: (2021)

Mechanistic analysis of multi-omics datasets to generate kinetic parameters for constraint-based metabolic models
por: Cotten, Cameron, et al.
Publicado: (2013)

A kinetic and mechanistic study into the transformation of calcium sulfate hemihydrate to dihydrate
por: Gurgul, Sebastian J., et al.
Publicado: (2019)

Improved Estimation of Human Lipoprotein Kinetics with Mixed Effects Models
por: Berglund, Martin, et al.
Publicado: (2015)

Association Between Lipids, Lipoproteins Composition of HDL Particles and Triglyceride-Rich Lipoproteins, and LCAT and CETP Activity in Post-renal Transplant Patients
por: Kimak, Elżbieta, et al.
Publicado: (2013)

Anacetrapib, a New CETP Inhibitor: The New Tool for the Management of Dyslipidemias?
por: Filippatos, Theodosios D., et al.
Publicado: (2017)

CETP, LIPC, and SCARB1 variants in individuals with extremely high high-density lipoprotein-cholesterol levels
por: Lee, Chan Joo, et al.
Publicado: (2019)

Kinetics of Turn-offs of Frog Rod Phototransduction Cascade
por: Astakhova, Luba A., et al.
Publicado: (2008)

Revisiting Trade-offs between Rubisco Kinetic Parameters
por: Flamholz, Avi I., et al.
Publicado: (2019)

CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects
por: Thomas, Tiffany, et al.
Publicado: (2017)

Mechanistic insight into 3‐methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate‐catabolizing bacteria
por: Shao, Xuan, et al.
Publicado: (2019)

CETP Activity: A Link between Lipid Metabolism and Coagulation System
por: Hatakeyama, Kinta
Publicado: (2016)

Kinetics and Mechanistic Studies on the Reaction between Cytochrome c and Tea Catechins
por: Wang, Lihua, et al.
Publicado: (2014)

Kinetic and mechanistic investigations of the degradation of propranolol in heat activated persulfate process
por: Gao, Yu-qiong, et al.
Publicado: (2018)

Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics
por: Raducanu, Vlad-Stefan, et al.
Publicado: (2022)

Photodegradation of Triclosan on the Kaolinite Surface: Kinetic, Mechanistic, and Molecular Modeling Approach
por: Le Fur, Cyril, et al.
Publicado: (2023)

Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study
por: Vo, Quan V., et al.
Publicado: (2019)

A generic approach to decipher the mechanistic pathway of heterogeneous protein aggregation kinetics
por: Tikader, Baishakhi, et al.
Publicado: (2021)

Kinetic and Mechanistic Studies of the Formation of Silver Nanoparticles by Nicotinamide as a Reducing Agent
por: Kumar, Indresh, et al.
Publicado: (2022)

Correction: An In-Silico Model of Lipoprotein Metabolism and Kinetics for the Evaluation of Targets and Biomarkers in the Reverse Cholesterol Transport Pathway
Publicado: (2014)

CETP and SGLT2 inhibitor combination therapy improves glycemic control
por: Khomtchouk, Bohdan B., et al.
Publicado: (2023)

Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects
por: Kim, Choon Ok, et al.
Publicado: (2016)

Kinetic Analysis of Swimming Flip-Turn Push-Off Techniques
por: Weimar, Wendi, et al.
Publicado: (2019)

Understanding off-target effects through hybridization kinetics and thermodynamics
por: Nazipova, Nafisa N., et al.
Publicado: (2019)

Quantitative Kinetic Analyses of Shutting Off a Two-Component System
por: Gao, Rong, et al.
Publicado: (2017)

Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors
por: Harada, Taku, et al.
Publicado: (2023)

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency
por: Meuser, Megan E., et al.
Publicado: (2018)

Thiosemicarbazone organocatalysis: tetrahydropyranylation and 2-deoxygalactosylation reactions and kinetics-based mechanistic investigation
por: Larsen, Dennis, et al.
Publicado: (2017)

Mechanistic and Kinetic Investigations on the Ozonolysis of Biomass Burning Products: Guaiacol, Syringol and Creosol
por: Chen, Xiaoxiao, et al.
Publicado: (2019)

Kinetics and mechanistic investigations on antiviral drug-valacyclovir hydrochloride by heptavalent alkaline permanganate
por: Tuwar, Suresh M, et al.
Publicado: (2021)

Iron-catalysed hydroboration of non-activated imines and nitriles: kinetic and mechanistic studies
por: Bazkiaei, Adineh Rezaei, et al.
Publicado: (2021)

Combining SIMS and mechanistic modelling to reveal nutrient kinetics in an algal-bacterial mutualism
por: Laeverenz Schlogelhofer, Hannah, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2uq81mr49tllnho2anrtols2s9